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Huntingtin is localized in the nucleus during preimplanatation embryo development in mice

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Jeong, Sung-Jin; Kim, Manho; Chang, Keun-A.; Kim, Hye-Sun; Park, Cheol-Hyoung; Suh, Yoo-Hun
Issue Date
2005-11-18
Publisher
Elsevier
Citation
Int J Dev Neurosci. 2006 Feb;24(1):81-5. Epub 2005 Nov 14.
Keywords
AnimalsBlastocyst/cytology/*metabolismCell Nucleus/*metabolismHumansHuntington DiseaseImmunohistochemistryMiceNerve Tissue Proteins/*metabolismNuclear Proteins/*metabolismOocytes/cytology/metabolism
Abstract
Huntington's disease (HD) is a dominant neurodegenerative disorder caused by the expansion of a CAG repeat in the gene encoding huntingtin. Moreover, the nuclear targeting of mutant huntingtin increases cellular toxicity, whereas normal huntingtin resides mainly in the cytoplasm, and is associated with membranes or microtubules. Huntingtin is enriched in neurons and its expression is increased during neural development. The inactivation of the HD gene results in embryonic lethality before nervous system development. Thus, huntingtin is critical during early embryonic development. Nevertheless, the function of huntingtin at this stage is unknown, even the distribution of the protein has not been described. The present study was undertaken to elucidate the distribution of huntingtin during the early developmental period in the mouse embryo. At the preimplantation stage, huntingtin was detected in nuclei up to 2.5 days post coitum (dpc), but disappeared from nuclei during the blastocyst stage (3.5 dpc). Following this stage, huntingtin was mainly localized in the cytoplasm and co-localized with mitotic spindles. These data suggest that the nuclear targeting of normal huntingtin is required during early embryo development in mice.
ISSN
0736-5748 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16289942

http://hdl.handle.net/10371/24464
DOI
https://doi.org/10.1016/j.ijdevneu.2005.10.001
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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