S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study
- Ham, Byung-Joo; Sung, Younghoon; Kim, Namkug; Kim, Seog Ju; Kim, Jieun E; Kim, Dajung J; Lee, Jeeyoung Y; Kim, Jihyun H; Yoon, Sujung J; Lyoo, In Kyoon
- Issue Date
- Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):403-11. Epub 2006 Dec 1.
- Adult; Basal Ganglia/*metabolism; Case-Control Studies; Choline/metabolism; Female; Gyrus Cinguli/*metabolism; Humans; Lactic Acid/metabolism; Magnetic Resonance Imaging/methods; Magnetic Resonance Spectroscopy/*methods; Male; Panic Disorder/*metabolism/*pathology; Protons; gamma-Aminobutyric Acid/*metabolism
- The purpose of this study was to investigate the brain gamma-aminobutyric acid (GABA) concentration and its relationship with clinical variables in patients with panic disorder (PD). Single voxel proton magnetic resonance spectroscopy ((1)H-MRS) scan was performed on 22 medicated subjects with PD and 25 age and sex-matched healthy comparison subjects. GABA and other metabolite levels were measured in the anterior cingulate cortex (ACC) and basal ganglia. GABA levels were significantly lower in the ACC and basal ganglia of PD patients relative to comparison subjects. Lactate and choline concentrations in the ACC in PD patients were also higher than in the comparison subjects. Our data suggested in part that alterations of the GABA function and the energy metabolism in ACC and basal ganglia may play an important role in the pathophysiology of panic disorder.
- 0278-5846 (Print)
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