S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients
- Kim, Minue J; Lyoo, In Kyoon; Dager, Stephen R; Friedman, Seth D; Chey, Jeanyung; Hwang, Jaeuk; Lee, Yu-Jin; Dunner, David L; Renshaw, Perry F
- Issue Date
- Bipolar Disord. 2007 May;9(3):274-80.
- Adolescent; Adult; Bipolar Disorder/*epidemiology/*pathology; Female; Humans; Magnetic Resonance Imaging/*statistics & numerical data; Male; Middle Aged; Prevalence; Septum Pellucidum/*pathology
- OBJECTIVES: This study was conducted to evaluate the prevalence of cavum septi pellucidi (CSP) enlargement in patients with bipolar disorder (BD) and healthy comparison subjects. METHODS: The occurrence of enlarged CSP in patients with BD (n = 41, age 35.4 +/- 10.8 years) and healthy volunteers (n = 41, age 35.3 +/- 10.0 years) was studied using magnetic resonance imaging. The length of the CSP was measured by counting the number of consecutive resliced coronal 0.5-mm images in which the CSP was present. A CSP length > or = 6 mm was a priori defined as abnormal enlargement of the CSP. RESULTS: Bipolar subjects exhibited a significantly higher prevalence of abnormal CSP enlargement (8 of 41 subjects, 19.5%) than healthy comparison subjects (1 of 41 subjects, 2.4%) (logistic regression analysis: Wald statistic = 5.07, df = 1, p = 0.024). The prevalence of abnormally enlarged CSP was not significantly different between drug-naive and drug-exposed bipolar subjects or when comparing bipolar I and II sub-diagnoses. Bipolar subjects with abnormal CSP enlargement had a significantly earlier onset of BD than those without (14.3 +/- 3.6 versus 20.1 +/- 7.4 years, respectively). CONCLUSIONS: The current study is the first to report an increased prevalence of abnormally enlarged CSP in a well-characterized bipolar population. Our finding that an abnormal enlargement of CSP, a neurodevelopmental abnormality, is associated with early onset of illness implicates early maturational processes as contributing to BD.
- 1398-5647 (Print)
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