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Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios

Cited 30 time in Web of Science Cited 35 time in Scopus
Authors
Kim, Soon Ae; Kim, Jin Hee; Park, Mira; Cho, In Hee; Yoo, Hee Jeong
Issue Date
2007-04-13
Publisher
Elsevier
Citation
Neurosci Res. 2007 Jul;58(3):332-5. Epub 2007 Mar 13.
Keywords
AdolescentAutistic Disorder/epidemiology/*geneticsChildChild, Preschool*Family HealthFemaleGene FrequencyGenotypeHumansKorea/epidemiologyLinkage DisequilibriumMalePolymorphism, Single Nucleotide/*geneticsReceptors, Kainic Acid/*genetics
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 (P<0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association (P=0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population.
ISSN
0168-0102 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17428563

https://hdl.handle.net/10371/24539
DOI
https://doi.org/10.1016/j.neures.2007.03.002
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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