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Epidermal growth factor 61 A/G polymorphism and uterine cervical cancer

Cited 21 time in Web of Science Cited 21 time in Scopus
Issue Date
2007-02-24
Publisher
Wiley-Blackwell
Citation
Int J Gynecol Cancer. 2007 Mar-Apr;17(2):492-6. Epub 2007 Feb 19.
Keywords
AdultAgedCarcinoma, Squamous Cell/epidemiology/*genetics/pathologyCase-Control StudiesCohort StudiesEpidermal Growth Factor/*geneticsFemaleGenetic Predisposition to DiseaseHumansLymphatic MetastasisMiddle AgedPolymorphism, Restriction Fragment LengthUterine Cervical Neoplasms/epidemiology/*genetics/pathologyPolymorphism, Single Nucleotide
Abstract
Cervical cancer, the second most common malignancy in women worldwide, is almost invariably associated with infection by human papillomavirus (HPV). However, although many women are infected with high-risk types of HPV, only a subset of infected women will ever develop cervical cancer. Therefore, host genetic factor may play a role in cervical carcinogenesis. Alterations in epidermal growth factor receptor (EGFR) are common events in cervical cancer. Therefore, we hypothesized that a functional polymorphism in the 5' untranslated region of the epidermal growth factor (EGF) gene, a natural ligand of the EGFR, may play a role in the cervical carcinogenesis and tumor invasiveness. We assessed the possible association between EGF +61 A/G polymorphism and cervical cancer risk in a hospital-based case-control study among 337 Korean women (168 cases, 169 age-matched controls). The frequencies of EGF +61 allele and genotype were not different between cases and controls. We observed increasing trend of lymph node metastasis from A/A homozygous genotype toward G/G homozygous genotype. We did not find any evidence that EGF +61 A/G polymorphism was associated with individual susceptibility of cervical cancer. However, although it was not statistically significant, the increasing trend of lymph node metastasis according to EGF genotype suggests the possibility that individual variance of EGF expression may be associated with cervical cancer invasiveness. We also confirmed that there exists striking ethnic heterogeneity of EGF genotype between Caucasian and East Asian population.
ISSN
1048-891X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17316357

https://hdl.handle.net/10371/24554
DOI
https://doi.org/10.1111/j.1525-1438.2007.00870.x
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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