Pharmacokinetics and tolerability of intravenous busulfan in hematopoietic stem cell transplantation

Cited 8 time in Web of Science Cited 10 time in Scopus

Cho, Yo-Han; Lim, Hyun-Ae; Lee, Mark Hong; Kim, Inho; Lee, Jong Seok; Park, Seong yang; Kim, Byoung Kook; Yoon, Sung-Soo

Issue Date
Clin Transplant. 2007 May-Jun;21(3):417-22.
AdolescentAdultArea Under CurveBusulfan/administration & dosage/*pharmacokineticsFemaleGranulocyte Colony-Stimulating Factor/therapeutic useHepatic Veno-Occlusive Disease/etiologyHumansInfusions, IntravenousLeukemia, Myelogenous, Chronic, BCR-ABL Positive/therapyMaleMiddle AgedPrecursor Cell Lymphoblastic Leukemia-Lymphoma/therapyHematopoietic Stem Cell Transplantation
Intravenous (IV) busulfan has been developed to overcome variable absorption of oral busulfan and tested in several trials. We tested its pharmacological properties and tolerability in 16 Korean stem cell transplantation (SCT) patients. IV busulfan was administered at 0.8 mg/kg every six h for a total of 16 doses (days -7 to -4), which was followed by cyclophosphamide administration at 60 mg/kg every 24 h for two d (days -3 and -2). The median AUC(inf) values (at the first dose) and AUC(ss) (at the steady state) were 1060.4 microM.min (range: 511.1-1812.7) and 1092.5 microM.min (range: 539.7-1560.8) respectively. All patients had an AUC(inf) of <1500 microM.min at the first dose, and 13 of the 16 (81.3%) maintained AUC(ss) levels between 800 and 1500 microM.min. Thirteen of 16 patients showed successful engraftments but four patients (25%) developed hepatic VOD (two of which were fatal), three of whom had advanced disease at the time of SCT. Overall, pharmacokinetics of IV busulfan in our SCT patients appeared comparable with those observed in other study. However, hepatic VOD was a major morbidity in patients with advanced disease.
0902-0063 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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