S-Space College of Medicine/School of Medicine (의과대학/대학원) Anatomy (해부학전공) Journal Papers (저널논문_해부학전공)
Immunohistochemical study on the distribution of the voltage-gated potassium channels in the gerbil cerebellum
- Chung, Yoon Hee; Joo, Kyeung Min; Nam, Ryoung Hee; Kim, Yang Soo; Lee, Won Bok; Cha, Chong Ik
- Issue Date
- Neurosci Lett. 2005 Feb 1;374(1):58-62.
- Animals; Cerebellum/cytology/*metabolism; Gerbillinae/*metabolism; Immunohistochemistry; Neurons/cytology/*metabolism; Potassium Channels, Voltage-Gated/*classification/*metabolism; Species Specificity; Tissue Distribution
- Although there have been many studies on the regional distribution of Kv channels in the rat and mouse cerebellum, there are no reports about Kv channel distribution in the gerbil, which is used as an ischemia animal model. Therefore, we aimed to investigate differences in the spatial patterning of Kv channel alpha-subunit isoforms in the gerbil cerebellum. The greatest concentration of Kv1.2 was found in the basket cell axon plexus and terminal regions around the Purkinje cells. Kv1.1 immunoreactivity was also concentrated in this area although the staining intensity was relatively lower. Both Purkinje cell layer and granular layer were intensely stained with anti-Kv1.3 and Kv1.6 antibodies, whereas immunoreactivities for Kv1.4 and Kv1.5 were detected in the Purkinje cell bodies with much lower intensity in the molecular and granular layers. In the cerebellar nuclei, the cell bodies of cerebellar output neurons showed strong immunoreactivities for Kv1.2, Kv1.4, and Kv1.6 with moderate staining for Kv1.3 and Kv1.5 in the cell bodies. This study on the differential localization patterns of Kv1 channel subunits in the gerbil cerebellum may provide helpful guidelines for correlating current types with particular channels and useful data for the future investigations on the pathological conditions such as ischemia and epilepsy.
- 0304-3940 (Print)
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