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Reduction of pain during induction with target-controlled propofol and remifentanil
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J. R. | - |
dc.contributor.author | Jung, C. W. | - |
dc.contributor.author | Lee, Y. H. | - |
dc.date.accessioned | 2009-12-31T08:07:55Z | - |
dc.date.available | 2009-12-31T08:07:55Z | - |
dc.date.issued | 2007-11-17 | - |
dc.identifier.citation | Br J Anaesth. 2007 Dec;99(6):876-80. | en |
dc.identifier.issn | 1471-6771 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18006530 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24697 | - |
dc.description.abstract | BACKGROUND: Pain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting where target-controlled infusions (TCI) of both drugs were used. A prospective, randomized, double-blind, placebo-controlled trial was performed to determine the effect-site concentration (Ce) of remifentanil to prevent the pain without producing complications. METHODS: A total of 128 patients undergoing general surgery were randomly allocated to receive normal saline (control) or remifentanil to a target Ce of 2 ng ml(-1) (R2), 4 ng ml(-1) (R4), or 6 ng ml(-1) (R6) administered via TCI. After the target Ce was achieved, the infusion of propofol was started. Remifentanil-related complications were assessed during the remifentanil infusion, and pain caused by propofol was evaluated using a four-point scale during the propofol infusion. RESULTS: The incidence of pain was significantly lower in Groups R4 and R6 than in the control and R2 groups (12/32 and 6/31 vs 26/31 and 25/32, respectively, P<0.001). Pain was less severe in Groups R4 and R6 than in the control and R2 groups (P<0.001). However, both incidence and severity of pain were not different between Groups R4 and R6. No significant complications were observed during the study. CONCLUSIONS: During induction of anaesthesia with TCI of propofol and remifentanil, a significant reduction in propofol infusion pain was achieved without significant complications by prior administration of remifentanil at a target Ce of 4 ng ml(-1). | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Analgesics, Opioid/adverse effects/*therapeutic use | en |
dc.subject | Anesthetics, Intravenous/administration & dosage/*adverse effects | en |
dc.subject | Double-Blind Method | en |
dc.subject | Drug Delivery Systems | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Infusions, Intravenous/adverse effects | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Pain/etiology/*prevention & control | en |
dc.subject | Pain Measurement/methods | en |
dc.subject | Piperidines/adverse effects/*therapeutic use | en |
dc.subject | Propofol/administration & dosage/*adverse effects | en |
dc.subject | Prospective Studies | en |
dc.title | Reduction of pain during induction with target-controlled propofol and remifentanil | en |
dc.type | Article | en |
dc.identifier.doi | 10.1093/bja/aem293 | - |
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