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The neurological safety of epidural gabapentin in rats: a light microscopic examination
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Sang-Sik | - |
dc.contributor.author | Kim, Yong-Chul | - |
dc.contributor.author | Lim, Young Jin | - |
dc.contributor.author | Lee, Chul-Joong | - |
dc.contributor.author | Lee, Pyung-Bok | - |
dc.contributor.author | Lee, Sang-Chul | - |
dc.contributor.author | Sim, Woo-Seok | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.date.accessioned | 2010-01-04T06:15:26Z | - |
dc.date.available | 2010-01-04T06:15:26Z | - |
dc.date.issued | 2005-10-26 | - |
dc.identifier.citation | Anesth Analg. 2005 Nov;101(5):1422-6. | en |
dc.identifier.issn | 0003-2999 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16244005 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24896 | - |
dc.description.abstract | Gabapentin acts primarily on the central nervous system. Therefore, we hypothesized that the direct epidural administration of gabapentin could have various advantages over its oral administration with respect to required dose, side effects, and efficacy. However, before administering gabapentin into the epidural space in a clinical setting, its neurotoxicity must be examined in animals. Thus, we evaluated neurotoxicity of epidural gabapentin by observing behavioral and sensory-motor changes, and by histopathological examinations of spinal cords and dorsal root ganglia in the rat. Twenty-seven rats were randomly divided into 3 groups, which were administered 0.3 mL (30 mg) of epidural gabapentin (group G, n = 9) and the same volume of epidural alcohol (group A, n = 9) or normal saline (group N, n = 9). No rats in groups G and N showed sensory-motor dysfunction, behavioral change, or histopathological abnormalities over a 3-wk observation period, whereas all rats in group A showed abnormalities. We conclude that the direct epidural injection of gabapentin in rats did not show any neurotoxic evidence in terms of sensory-motor functions and behavior, or by a microscopic histopathological evaluation. This study represents a first promising step toward the trial of epidural gabapentin in a clinical setting. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Amines/administration & dosage/*toxicity | en |
dc.subject | Animals | en |
dc.subject | Cyclohexanecarboxylic Acids/administration & dosage/*toxicity | en |
dc.subject | Ganglia, Spinal/drug effects/pathology | en |
dc.subject | Injections, Epidural | en |
dc.subject | Male | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Spinal Cord/*drug effects/pathology | en |
dc.subject | gamma-Aminobutyric Acid/administration & dosage/*toxicity | en |
dc.title | The neurological safety of epidural gabapentin in rats: a light microscopic examination | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최상식 | - |
dc.contributor.AlternativeAuthor | 김용철 | - |
dc.contributor.AlternativeAuthor | 임영진 | - |
dc.contributor.AlternativeAuthor | 이철중 | - |
dc.contributor.AlternativeAuthor | 이평복 | - |
dc.contributor.AlternativeAuthor | 이상철 | - |
dc.contributor.AlternativeAuthor | 심우석 | - |
dc.contributor.AlternativeAuthor | 최윤라 | - |
dc.identifier.doi | 10.1213/01.ANE.0000180197.32577.9B | - |
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