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Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy

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dc.contributor.authorKim, Dajung J.-
dc.contributor.authorLyoo, In Kyoon-
dc.contributor.authorYoon, Sujung J-
dc.contributor.authorChoi, Taeyoung-
dc.contributor.authorLee, Byungchol-
dc.contributor.authorKim, Jieun E-
dc.contributor.authorLee, Joonsun S-
dc.contributor.authorRenshaw, Perry F-
dc.date.accessioned2010-01-04T06:57:04Z-
dc.date.available2010-01-04T06:57:04Z-
dc.date.issued2007-05-29-
dc.identifier.citationProg Neuropsychopharmacol Biol Psychiatry 2007;31:1182-1188en
dc.identifier.issn0278-5846 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17532107-
dc.identifier.urihttps://hdl.handle.net/10371/24899-
dc.description.abstractThe aim of the current study was to evaluate the relationship between quetiapine's effect on the improvement of mood symptoms in bipolar patients and brain metabolite level changes as measured by proton magnetic resonance spectroscopy ((1)H-MRS). Rapid cycling bipolar patients in the manic state were recruited and treated with quetiapine for 12 weeks. Clinical assessment was performed using the Young Mania Rating Scale (YMRS), the 17-item Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression-Severity scale (CGI-S) at baseline and weekly intervals during the 12-week period. In order to evaluate metabolite level changes over time, (1)H-MRS scans were acquired at baseline and week 12. There were significant reductions in YMRS scores (by 43.0%), HDRS scores (by 27.5%) and CGI-S score (by 44.6%) over the 12 week-period. Lactate levels significantly decreased over the 12-week study period (22.4%). This change in lactate levels was more prominent in quetiapine responders than in non-responders. Additionally, there was a positive correlation between changes in lactate levels and those in YMRS scores (r=0.52, p=0.003). Our findings suggest that quetiapine's antimanic and antidepressant efficacy in patients with rapid cycling bipolar disorder may potentially be related to decreased lactate levels in frontal regions of the brain.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAnalysis of Varianceen
dc.subjectAntipsychotic Agents/*administration & dosageen
dc.subjectBipolar Disorder/drug therapy/*metabolism/pathologyen
dc.subjectDibenzothiazepines/*administration & dosageen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLactic Acid/*metabolismen
dc.subjectMagnetic Resonance Imaging/methodsen
dc.subjectMagnetic Resonance Spectroscopy/*methodsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProtons/*diagnostic useen
dc.subjectSeverity of Illness Indexen
dc.titleClinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopyen
dc.typeArticleen
dc.contributor.AlternativeAuthor김대중-
dc.contributor.AlternativeAuthor류인균-
dc.contributor.AlternativeAuthor윤수정-
dc.contributor.AlternativeAuthor최태영-
dc.contributor.AlternativeAuthor이병철-
dc.contributor.AlternativeAuthor김지은-
dc.contributor.AlternativeAuthor이준선-
dc.identifier.doi10.1016/j.pnpbp.2007.04.009-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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