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Effect of salicylic acid on invasion of human vascular endothelial cells by Staphylococcus aureus

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Park, Wan Beom; Kim, Sung-Han; Cho, Jae Hyun; Bang, Ji Hwan; Kim, Hong Bin; Kim, Nam Joong; Oh, Myoung-don; Choe, Kang Won
Issue Date
2007
Publisher
Wiley-Blackwell
Citation
FEMS Immunol Med Microbiol 49: 56-61
Keywords
Bacterial Adhesion/drug effectsEndothelial Cells/*drug effects/immunology/*microbiologyHumansInterleukin-6/biosynthesis/immunologySalicylic Acid/*pharmacologyStaphylococcal Infections/microbiologyStaphylococcus aureus/*drug effects/pathogenicity
Abstract
Invasion of vascular endothelial cells by Staphylococcus aureus is associated with diverse complications and recurrent infection. Little is known about the effect of salicylic acid, the major metabolite of aspirin, on the interaction between S. aureus and vascular endothelial cells. We examined the adhesion of S. aureus strain 8325-4 cultured with or without salicylic acid to human umbilical vein endothelial cells (HUVECs), and the ability of the strain to invade these cells. Strain 8325-4 cells grown in salicylic acid were significantly less adherent to and invasive in HUVECs. Production of cytokine interleukin (IL)-6 was lower from the HUVECs infected with clinical isolates of S. aureus cultured in salicylic acid compared with those unexposed to salicylic acid. This study raises the possibility of using salicylic acid as an adjuvant therapeutic agent in the treatment of S. aureus bacteremia to prevent its complications or recurrence.
ISSN
0928-8244 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17094786

http://hdl.handle.net/10371/24914
DOI
https://doi.org/10.1111/j.1574-695X.2006.00170.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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