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Proteasomal inhibition in intracerebral hemorrhage: neuroprotective and anti-inflammatory effects of bortezomib
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sinn, Dong-In | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Kim, Jeong-Min | - |
dc.contributor.author | Park, Dong-Kyu | - |
dc.contributor.author | Song, Eun-Cheol | - |
dc.contributor.author | Kim, Byung-Su | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Roh, Jae-Kyu | - |
dc.date.accessioned | 2010-01-05T07:41:11Z | - |
dc.date.available | 2010-01-05T07:41:11Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Neurosci. Res. 58, 12-18 | en |
dc.identifier.issn | 0168-0102 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17328981 | - |
dc.identifier.uri | https://hdl.handle.net/10371/25597 | - |
dc.description.abstract | Inflammation is an important pathophysiologic mechanism of injury induced by intracerebral hemorrhage (ICH). The ubiquitin-proteasome system (UPS) regulates the inflammatory responses via the up-regulation of several pro-inflammatory molecules. In this study, we determined that a potent proteasome inhibitor, bortezomib, exerted therapeutic effects in experimental model of ICH. Either bortezomib (0.05, 0.2, 0.5, 1mg/kg) or vehicle was intravenously administered 2h after ICH induction. The high doses of bortezomib caused high mortality rates. Bortezomib at 0.2 mg/kg reduced the early hematoma growth and alleviated hematoma volume and brain edema at 3 days after ICH, compared with the ICH-vehicle group. The numbers of myeloperoxidase(+) neutrophils, Ox42(+) microglia, and TUNEL(+) cells in the perihematomal regions were decreased by bortezomib. Bortezomib induced significant decrements of mRNA expression of TNF-alpha and IL-6. The production of iNOS and COX2 was also reduced significantly by bortezomib. We concluded that the early treatment with bortezomib induced a reduction in the early hematoma growth and mitigated the development of brain edema, coupled with a marked inhibitory effect on inflammation in ICH. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Anti-Inflammatory Agents/pharmacology | en |
dc.subject | Biological Markers/analysis/metabolism | en |
dc.subject | Boronic Acids/*pharmacology | en |
dc.subject | Brain Edema/drug therapy/etiology/physiopathology | en |
dc.subject | Cerebral Cortex/blood supply/*drug effects/physiopathology | en |
dc.subject | Cerebral Hemorrhage/complications/*drug therapy/physiopathology | en |
dc.subject | Cytokines/antagonists & inhibitors/genetics | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Encephalitis/*drug therapy/etiology/physiopathology | en |
dc.subject | Gliosis/drug therapy/etiology/physiopathology | en |
dc.subject | Inflammation Mediators/antagonists & inhibitors/metabolism | en |
dc.subject | Male | en |
dc.subject | Microglia/drug effects/immunology/metabolism | en |
dc.subject | Neuroprotective Agents/pharmacology | en |
dc.subject | Neutrophils/drug effects/immunology/metabolism | en |
dc.subject | Protease Inhibitors/*pharmacology | en |
dc.subject | Proteasome Endopeptidase Complex/*drug effects/metabolism | en |
dc.subject | Pyrazines/*pharmacology | en |
dc.subject | RNA, Messenger/drug effects/metabolism | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Treatment Outcome | en |
dc.title | Proteasomal inhibition in intracerebral hemorrhage: neuroprotective and anti-inflammatory effects of bortezomib | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신동인 | - |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 김은희 | - |
dc.contributor.AlternativeAuthor | 김정민 | - |
dc.contributor.AlternativeAuthor | 박동규 | - |
dc.contributor.AlternativeAuthor | 송은철 | - |
dc.contributor.AlternativeAuthor | 김병수 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.identifier.doi | 10.1016/j.neures.2007.01.006 | - |
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