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Evaluation of cytokine mRNA in induced sputum from patients with allergic rhinitis: relationship to airway hyperresponsiveness

Cited 30 time in Web of Science Cited 28 time in Scopus
Authors
Sohn, S-W; Lee, H-S; Park, H-W; Chang, Y-S; Kim, Y-K; Cho, S-H; Kim, Y-Y; Min, K-U
Issue Date
2007-12-07
Publisher
Wiley-Blackwell
Citation
Allergy 2008;63:268-273
Keywords
Asthma/*metabolism/*physiopathologyBronchial Hyperreactivity/*diagnosis/metabolismBronchial Provocation TestsCase-Control StudiesCohort StudiesCytokines/analysis/*metabolismEvaluation Studies as TopicInflammation Mediators/analysisProbabilityRNA, Messenger/analysisReference ValuesRespiratory Function TestsReverse Transcriptase Polymerase Chain ReactionRhinitis, Allergic, Perennial/*diagnosis/metabolismRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSputum/chemistryStatistics, Nonparametric
Abstract
BACKGROUND: Although airway hyperresponsiveness (AHR) is a characteristic feature of asthma, it is also frequently present in allergic rhinitis (AR). However, the pathogenesis of AHR is unclear and the roles of cytokines in the airway have not been well established in AR. We sought to compare cytokine mRNA levels in the sputum of AR patients with or without AHR and those of asthma patients, and to evaluate whether differences in cytokine levels are associated with the development of an abnormal airway response and the absence of respiratory symptoms in AR patients with AHR. METHODS: Airway cells were obtained by sputum induction from 18 AR patients with AHR, 58 AR patients without AHR, and 27 asthma patients. Airway cell cytokine levels, interleukin (IL) -4, IL-5, IL-13, vascular endothelial growth factor (VEGF), and interferon-gamma (IFN-gamma), were studied at the mRNA level by RT-PCR. RESULTS: Vascular endothelial growth factor and IL-5 mRNA levels were significantly higher in AR patients with AHR than in AR patients without AHR, but these were lower than those of asthmatic patients. Eosinophils were significantly higher in AR patients with AHR and in asthmatic patients than in AR patients without AHR. Interleukin-4, IL-13, and IFN-gamma levels were not elevated in AR patients with or without AHR vs asthma patients. CONCLUSIONS: These findings suggest that VEGF and IL-5 can be important determinants of the development of AHR in AR patients and that lower levels of other cytokines may be associated with the absence of asthmatic symptoms in AR patients with AHR.
ISSN
1398-9995 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18053010

https://hdl.handle.net/10371/25655
DOI
https://doi.org/10.1111/j.1398-9995.2007.01550.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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