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Quantitative analysis of group-specific brain tissue probability map for schizophrenic patients

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dc.contributor.authorYoon, Uicheul-
dc.contributor.authorLee, Jong-Min-
dc.contributor.authorShin, Yong-Wook-
dc.contributor.authorLee, Kyung Jin-
dc.contributor.authorKim, In Young-
dc.contributor.authorKwon, Jun Soo-
dc.contributor.authorKim, Sun I-
dc.date.accessioned2010-01-06T02:17:09Z-
dc.date.available2010-01-06T02:17:09Z-
dc.date.issued2005-05-24-
dc.identifier.citationNeuroimage. 2005 Jun;26(2):502-12. Epub 2005 Apr 7.en
dc.identifier.issn1053-8119 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15907307-
dc.identifier.urihttps://hdl.handle.net/10371/25960-
dc.description.abstractWe developed group-specific tissue probability map (TPM) for gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) on the common spatial coordinates of an averaged brain atlas derived from normal controls (NC) and from schizophrenic patients (SZ). To identify differences in group-specific TPMs, we used quantitative evaluation methods based on differences in probabilistic distribution as a global criterion, and the mean probability and the similarity index (SI) by lobe as regional criteria. The SZ group showed more spatial variation with a lower mean probability than NC subjects. And, for the right temporal and left parietal lobes, the SI between each group was lower than the other lobes. It can be said that there were significant differences in spatial distribution between controls and schizophrenic patients at those areas. In case of female group, although group differences in the volumes of GM and WM were not significant, global difference in the probabilistic distribution of GM was more prominent and the SI was lower and its descent rate was greater in all lobes, compared with the male group. If these morphological differences caused by disease or group-specific features were not considered in TPM, the accuracy and certainty of specific group studies would be greatly reduced. Therefore, suitable TPM is required as a common framework for functional neuroimaging studies and an a priori knowledge of tissue classification.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectBrain/*pathologyen
dc.subjectBrain Mappingen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Interpretation, Computer-Assisteden
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectModels, Statisticalen
dc.subjectProbabilityen
dc.subjectSchizophrenia/*pathologyen
dc.subjectSex Characteristicsen
dc.titleQuantitative analysis of group-specific brain tissue probability map for schizophrenic patientsen
dc.typeArticleen
dc.contributor.AlternativeAuthor윤의철-
dc.contributor.AlternativeAuthor이종민-
dc.contributor.AlternativeAuthor신용욱-
dc.contributor.AlternativeAuthor이경진-
dc.contributor.AlternativeAuthor김인영-
dc.contributor.AlternativeAuthor권준수-
dc.contributor.AlternativeAuthor김선이-
dc.identifier.doi10.1016/j.neuroimage.2005.01.056-
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