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Alpha-antitrypsin genotypes in Korean patients with chronic obstructive pulmonary disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Cheol Hyeon | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.date.accessioned | 2010-01-06T06:31:13Z | - |
dc.date.available | 2010-01-06T06:31:13Z | - |
dc.date.issued | 2005-04-13 | - |
dc.identifier.citation | Respirology. 2005 Mar;10(2):223-8. | en |
dc.identifier.issn | 1323-7799 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15823189 | - |
dc.identifier.uri | https://hdl.handle.net/10371/26502 | - |
dc.description.abstract | OBJECTIVE: Alpha1-antitrypsin (AAT) deficiency is a recognized susceptible factor for chronic obstructive pulmonary disease (COPD) in Western countries, but its importance in Korea is unclear. To date, no definitive case of alpha1-antitrypsin deficiency has been reported in Korea. This study aimed to clarify whether alpha1-antitrypsin deficiency exists and to determine the distribution of alpha1-antitrypsin alleles in the Korean population. METHODOLOGY: The serum concentrations of alpha1-antitrypsin were determined and polymorphisms of the alpha1-antitrypsin gene in 114 COPD patients and in 196 healthy controls were examined. Phenotyping by isoelectric focusing and the genotyping of alpha1-antitrypsin gene by polymerase chain reaction and restriction fragment length polymorphism were performed. RESULTS: No alpha1-antitrypsin level abnormality was found in the patients. M1(Val)/M1(Val) was found to be the most frequent genotype in both groups (69.2% and 66.8%, respectively), and M1(Val) the most frequent allele. The distributions of alpha1-antitrypsin alleles were similar in the patient and control groups, and no S or Z allele was found. CONCLUSION: Alpha1-antitrypsin deficiency is unlikely to be an important cause of chronic obstructive pulmonary disease in the Korean population. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Alleles | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | Polymorphism, Restriction Fragment Length | en |
dc.subject | Pulmonary Disease, Chronic Obstructive/blood/*genetics/physiopathology | en |
dc.subject | Respiratory Function Tests | en |
dc.subject | alpha 1-Antitrypsin/analysis/*genetics | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Alpha-antitrypsin genotypes in Korean patients with chronic obstructive pulmonary disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김철현 | - |
dc.contributor.AlternativeAuthor | 임재준 | - |
dc.contributor.AlternativeAuthor | 유철규 | - |
dc.contributor.AlternativeAuthor | 이춘택 | - |
dc.contributor.AlternativeAuthor | 김영환 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 심영수 | - |
dc.identifier.doi | 10.1111/j.1440-1843.2005.00693.x | - |
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