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The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail-induced apoptosis in HeLa cells
Cited 18 time in
Web of Science
Cited 18 time in Scopus
- Authors
- Issue Date
- 2005-11-25
- Publisher
- Taylor & Francis
- Citation
- Cancer Invest. 2005;23(7):586-92.
- Keywords
- Apoptosis Regulatory Proteins/*physiology ; Down-Regulation ; Enzyme Activation ; Genes, bcl-2 ; Hela Cells ; Humans ; Membrane Glycoproteins/*physiology ; Mitogen-Activated Protein Kinase 3/*metabolism ; Protein-Tyrosine Kinases/metabolism ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha/*physiology ; Up-Regulation ; Apoptosis
- Abstract
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) serves as an extracellular signal that triggers apoptosis in tumor cells. To characterize the molecular events involved in TRAIL-induced apoptotic signaling, we investigated the role of extracellular signal-regulated kinase 1/2 (ERK1/2) in HeLa cell death. Here we show that TRAIL-activated ERK1/2 through a tyrosine kinase-dependent pathway, subsequently elevated anti-apoptotic Bcl-2 protein levels. ERK1/2 inhibition with PD98059 promoted apoptotic cell death through the downregulation of ERK1/2 activity and Bcl-2 protein levels. Moreover, tyrosine kinase inhibition with Genistein in TRAIL-induced apoptosis effectively attenuated ERK1/2 activity and enhanced apoptotic cell death. Taken together, our results indicate that ERK1/2 activation via tyrosine kinase pathway plays a protective role as the cellular defense mechanism through the upregulation of Bcl-2 protein levels in TRAIL-induced apoptosis.
- ISSN
- 0735-7907 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16305985
https://hdl.handle.net/10371/26605
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