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Relationships of methacholine and AMP responsiveness with peak expiratory flow variability in children with asthma

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors
Yoo, Y; Kim, D K; Yu, J; Choi, S H; Kim, C K; Koh, Y Y
Issue Date
2007-07-27
Publisher
Wiley-Blackwell
Citation
Clin Exp Allergy. 2007 Aug;37(8):1158-64.
Keywords
Adenosine Monophosphate/*administration & dosageAdolescentAsthma/diagnosis/*physiopathologyBronchial Provocation TestsChildFemaleFollow-Up StudiesHumansMaleMethacholine Chloride/*administration & dosageMuscarinic Agonists/*administration & dosagePeak Expiratory Flow Rate/*drug effectsReproducibility of Results
Abstract
BACKGROUND: Both bronchial responsiveness (BR) and peak expiratory flow (PEF) variability are increased in asthma. PEF variability is presumed to reflect the degree of BR in asthma. BR is commonly assessed by bronchial challenges using direct or indirect stimuli. OBJECTIVE: The aim of this study was to compare methacholine and adenosine 5'-monophosphate (AMP) responsiveness with regard to their relationships with PEF variability in children with asthma. METHODS: Methacholine and AMP challenge tests were performed in 79 children with mild to moderate asthma, and a provocative concentration causing a 20% decline in forced expiratory volume in 1 s (PC(20)) was calculated for each challenge. Subjects recorded PEF each morning and each evening for 14 consecutive days. PEF variability was expressed as amplitude percentage mean (amp%mean; high PEF minus low PEF on each day, expressed as a percentage of their mean, averaged over 14 days), and as the lowest percentage highest (low%high; the lowest PEF expressed as a percentage of the highest PEF recorded over the period). RESULTS: Methacholine PC(20) correlated significantly but weakly with both indices of PEF variability (amp%mean: r=-0.285, P=0.011; low%high: r=0.238, P=0.034). However, there was a significant and strong correlation between AMP PC(20) and both amp%mean (r=-0.583, P=0.000) and low%high (r=0.496, P=0.000). For AMP PC(20), the correlations were stronger than for methacholine PC(20) (comparison of correlation coefficients with amp%mean: P=0.021; with low%high: P=0.063). CONCLUSION: Both methacholine PC(20) and AMP PC(20) correlated significantly with PEF variability. However, the stronger correlations for AMP PC(20) than for methacholine PC(20) suggest that PEF variability may be better reflected by BR assessed by AMP than by methacholine.
ISSN
0954-7894 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17651145

http://hdl.handle.net/10371/26614
DOI
https://doi.org/10.1111/j.1365-2222.2007.02766.x
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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