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Direct modulation of Ca(2+)-activated K(+) current by H-89 in rabbit coronary arterial smooth muscle cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Son, Youn Kyoung | - |
dc.contributor.author | Kim, Nari | - |
dc.contributor.author | Youm, Jae Boum | - |
dc.contributor.author | Warda, Mohamad | - |
dc.contributor.author | Ko, Jae-Hong | - |
dc.contributor.author | Ko, Eun A | - |
dc.contributor.author | Kang, Sung Hyun | - |
dc.contributor.author | Kim, Euiyong | - |
dc.contributor.author | Earm, Yung E. | - |
dc.contributor.author | Han, Jin | - |
dc.date.accessioned | 2010-01-06T06:52:45Z | - |
dc.date.available | 2010-01-06T06:52:45Z | - |
dc.date.issued | 2006-10-21 | - |
dc.identifier.citation | Vascul Pharmacol. 2007 Feb;46(2):105-13. Epub 2006 Sep 8. | en |
dc.identifier.issn | 1537-1891 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17052962 | - |
dc.identifier.uri | https://hdl.handle.net/10371/26635 | - |
dc.description.abstract | The effects of H-89, a potent and selective inhibitor of protein kinase A (PKA) on Ca(2+)-activated K(+) (BK(Ca)) channels in coronary arterial smooth muscle cells were examined using a patch-clamp technique. In inside-out configuration, H-89 increased the NP(o) of the BK(Ca) channel, but it reduced the dwell time of BK(Ca) currents. In whole-cell configuration, H-89 markedly increased BK(Ca) currents in a concentration-dependent manner. The EC(50) was 0.470+/-0.0741 microM based on dwell time, 0.582+/-0.0691 microM based on the NP(o), and 0.519+/-0.0295 microM based on the whole-cell current, respectively. H-85, which is an inactive form of H-89, increased BK(Ca) currents, similar to the result of H-89. The other PKA inhibitors (Rp-8-CPT-cAMPs and KT 5720) and protein phosphatase inhibitor (okadaic acid, 1 microM) had little effect on BK(Ca) currents and did not significantly alter the stimulatory effects of 1 microM H-89. These findings suggest that H-89 increases the BK(Ca) current independently of PKA. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Carbazoles/pharmacology | en |
dc.subject | Coronary Circulation/drug effects | en |
dc.subject | Coronary Vessels/drug effects/metabolism | en |
dc.subject | Cyclic AMP/analogs & derivatives/pharmacology | en |
dc.subject | Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Enzyme Inhibitors/pharmacology | en |
dc.subject | Indoles/pharmacology | en |
dc.subject | Isoquinolines/*pharmacology | en |
dc.subject | Membrane Potentials/drug effects | en |
dc.subject | Muscle, Smooth, Vascular/*drug effects/metabolism | en |
dc.subject | Okadaic Acid/pharmacology | en |
dc.subject | Patch-Clamp Techniques | en |
dc.subject | Phosphoprotein Phosphatases/antagonists & inhibitors | en |
dc.subject | Potassium Channels, Calcium-Activated/*drug effects/metabolism | en |
dc.subject | Protein Kinase Inhibitors/*pharmacology | en |
dc.subject | Pyrroles/pharmacology | en |
dc.subject | Rabbits | en |
dc.subject | Sulfonamides/*pharmacology | en |
dc.subject | Thionucleotides/pharmacology | en |
dc.subject | Time Factors | en |
dc.subject | Vascular Resistance/drug effects | en |
dc.title | Direct modulation of Ca(2+)-activated K(+) current by H-89 in rabbit coronary arterial smooth muscle cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박원선 | - |
dc.contributor.AlternativeAuthor | 손윤경 | - |
dc.contributor.AlternativeAuthor | 김나리 | - |
dc.contributor.AlternativeAuthor | 염재범 | - |
dc.contributor.AlternativeAuthor | 고재홍 | - |
dc.contributor.AlternativeAuthor | 고은아 | - |
dc.contributor.AlternativeAuthor | 강성현 | - |
dc.contributor.AlternativeAuthor | 김의용 | - |
dc.contributor.AlternativeAuthor | 엄융의 | - |
dc.contributor.AlternativeAuthor | 한진 | - |
dc.identifier.doi | 10.1016/j.vph.2006.08.413 | - |
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