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Prefrontal and temporal gray matter density decreases in opiate dependence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Pollack, Mark H | - |
dc.contributor.author | Silveri, Marisa M | - |
dc.contributor.author | Ahn, Kyung Heup | - |
dc.contributor.author | Diaz, Claudia I | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Yurgelun-Todd, Deborah A | - |
dc.contributor.author | Kaufman, Marc J | - |
dc.contributor.author | Renshaw, Perry F | - |
dc.date.accessioned | 2010-01-06T07:54:56Z | - |
dc.date.available | 2010-01-06T07:54:56Z | - |
dc.date.issued | 2005-12-22 | - |
dc.identifier.citation | Psychopharmacology (Berl). 2006 Jan;184(2):139-44. Epub 2005 Dec 21. | en |
dc.identifier.issn | 0033-3158 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16369836 | - |
dc.identifier.uri | https://hdl.handle.net/10371/26841 | - |
dc.description.abstract | RATIONALE: There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects. OBJECTIVES: The objective of the current study is to explore gray matter density in opiate-dependent subjects. METHODS: Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM. RESULTS: Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28). CONCLUSIONS: This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Axons/physiology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Image Interpretation, Computer-Assisted | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Male | en |
dc.subject | Opioid-Related Disorders/cerebrospinal fluid/*pathology | en |
dc.subject | Prefrontal Cortex/*pathology | en |
dc.subject | Psychiatric Status Rating Scales | en |
dc.subject | Temporal Lobe/*pathology | en |
dc.title | Prefrontal and temporal gray matter density decreases in opiate dependence | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 류인균 | - |
dc.contributor.AlternativeAuthor | 안경흡 | - |
dc.contributor.AlternativeAuthor | 황재욱 | - |
dc.contributor.AlternativeAuthor | 김석주 | - |
dc.identifier.doi | 10.1007/s00213-005-0198-x | - |
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