Browse

Prefrontal and temporal gray matter density decreases in opiate dependence

DC Field Value Language
dc.contributor.authorLyoo, In Kyoon-
dc.contributor.authorPollack, Mark H-
dc.contributor.authorSilveri, Marisa M-
dc.contributor.authorAhn, Kyung Heup-
dc.contributor.authorDiaz, Claudia I-
dc.contributor.authorHwang, Jaeuk-
dc.contributor.authorKim, Seog Ju-
dc.contributor.authorYurgelun-Todd, Deborah A-
dc.contributor.authorKaufman, Marc J-
dc.contributor.authorRenshaw, Perry F-
dc.date.accessioned2010-01-06T07:54:56Z-
dc.date.available2010-01-06T07:54:56Z-
dc.date.issued2005-12-22-
dc.identifier.citationPsychopharmacology (Berl). 2006 Jan;184(2):139-44. Epub 2005 Dec 21.en
dc.identifier.issn0033-3158 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16369836-
dc.identifier.urihttps://hdl.handle.net/10371/26841-
dc.description.abstractRATIONALE: There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects. OBJECTIVES: The objective of the current study is to explore gray matter density in opiate-dependent subjects. METHODS: Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM. RESULTS: Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28). CONCLUSIONS: This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAdulten
dc.subjectAxons/physiologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Interpretation, Computer-Assisteden
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectOpioid-Related Disorders/cerebrospinal fluid/*pathologyen
dc.subjectPrefrontal Cortex/*pathologyen
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectTemporal Lobe/*pathologyen
dc.titlePrefrontal and temporal gray matter density decreases in opiate dependenceen
dc.typeArticleen
dc.contributor.AlternativeAuthor류인균-
dc.contributor.AlternativeAuthor안경흡-
dc.contributor.AlternativeAuthor황재욱-
dc.contributor.AlternativeAuthor김석주-
dc.identifier.doi10.1007/s00213-005-0198-x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse