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Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Sung Jun | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Park, Yun Kyung | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Cho, Kwangwook | - |
dc.contributor.author | Kim, Jun | - |
dc.date.accessioned | 2010-01-07 | - |
dc.date.available | 2010-01-07 | - |
dc.date.issued | 2006-07-14 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2006 Aug 25;347(2):509-16. Epub 2006 Jun 30. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16836978 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27289 | - |
dc.description.abstract | The spinal synaptic plasticity is associated with a central sensitization of nociceptive input, which accounts for the generation of hyperalgesia in chronic pain. However, how group I metabotropic glutamate receptors (mGluRs) may operate spinal plasticity remains essentially unexplored. Here, we have identified spike-timing dependent synaptic plasticity in substantia gelatinosa (SG) neurons, using perforated patch-clamp recordings of SG neuron in a spinal cord slice preparation. In the presence of bicuculline and strychnine, long-term potentiation (LTP) was blocked by AP-5 and Ca2+ chelator BAPTA-AM. The group I mGluR antagonist AIDA, PLC inhibitor U-73122, and IP3 receptor blocker 2-APB shifted LTP to long-term depression (LTD) without affecting acute synaptic transmission. These findings provide a link between postsynaptic group I mGluR/PLC/IP3-gated Ca2+ store regulating the polarity of synaptic plasticity and spinal central sensitization. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | 2-Amino-5-phosphonovalerate/pharmacology | en |
dc.subject | Animals | en |
dc.subject | Boron Compounds/pharmacology | en |
dc.subject | Calcium/antagonists & inhibitors/metabolism | en |
dc.subject | Calcium Channels | en |
dc.subject | Chelating Agents/pharmacology | en |
dc.subject | Egtazic Acid/analogs & derivatives/pharmacology | en |
dc.subject | Estrenes/pharmacology | en |
dc.subject | Excitatory Amino Acid Antagonists/pharmacology | en |
dc.subject | Female | en |
dc.subject | Indans/pharmacology | en |
dc.subject | Inositol 1,4,5-Trisphosphate Receptors | en |
dc.subject | Long-Term Potentiation/drug effects/physiology | en |
dc.subject | Long-Term Synaptic Depression/drug effects/physiology | en |
dc.subject | Male | en |
dc.subject | Neuronal Plasticity/drug effects/*physiology | en |
dc.subject | Neurons/drug effects/*physiology | en |
dc.subject | Pyrrolidinones/pharmacology | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors | en |
dc.subject | Receptors, Metabotropic Glutamate/antagonists & inhibitors/*physiology | en |
dc.subject | Staurosporine/pharmacology | en |
dc.subject | Substantia Gelatinosa/cytology/drug effects/*physiology | en |
dc.subject | Synaptic Transmission/drug effects/*physiology | en |
dc.subject | Time Factors | en |
dc.subject | Type C Phospholipases/antagonists & inhibitors | en |
dc.title | Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정성준 | - |
dc.contributor.AlternativeAuthor | 김상정 | - |
dc.contributor.AlternativeAuthor | 박윤경 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.contributor.AlternativeAuthor | 조광욱 | - |
dc.contributor.AlternativeAuthor | 김준 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.06.134 | - |
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