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Evaluation of immediate post-stress wall motion on adenosine stress/rest thallium-201 gated myocardial SPECT

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dc.contributor.authorLee, Won Woo-
dc.contributor.authorPark, Eun Kyung-
dc.contributor.authorEo, Jae Seon-
dc.contributor.authorLee, Sang Woo-
dc.contributor.authorKim, Cheol Ho-
dc.contributor.authorSo, Young-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorChung, June-Key-
dc.contributor.authorLee, Myung Chul-
dc.contributor.authorKim, Sang Eun-
dc.date.accessioned2010-01-07-
dc.date.available2010-01-07-
dc.date.issued2005-08-04-
dc.identifier.citationInt J Cardiovasc Imaging. 2006 Apr;22(2):213-22. Epub 2005 Aug 18.en
dc.identifier.issn1569-5794 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16078001-
dc.identifier.urihttps://hdl.handle.net/10371/27343-
dc.description.abstractAs early as 10 min after adenosine stress, immediate post-stress wall motion can be evaluated on adenosine stress/rest Tl-201 gated myocardial SPECT. To widen the applications of Tl-201 in gated SPECT, we investigated the reproducibility of LV parameters (EF, EDV, and ESV), and the diagnostic competency of immediate post-stress wall motion evaluations obtained by adenosine stress/rest Tl-201 gated myocardial SPECT. Myocardial perfusion and wall motion were evaluated using a 5-point scoring system in 20-segment model using Cedas automatic gated software (AutoQUANT 4.3.1). The reproducibilities of LV parameters were examined through repeated acquisition (n=31). Diagnostic competency was evaluated vs. coronary angiography, and multivariate logistic regression analysis was used to determine whether stress abnormal perfusion (SSSp), stress abnormal wall motion (SSSwm), or reversible abnormal wall motion (SDSwm) predict coronary stenosis (>70%) (n=60). Two standard deviations for immediate post-stress wall motion were smaller than those for rest at EF (8.6 vs. 10.7%) and ESV (6.0 ml vs 8.4 ml). Univariate logistic regression analysis identified SSSp (p=0.006), SSSwm (p=0.016), and SDSwm (p=0.020) are significant predictors, but only SSSp (p=0.013) and SDSwm (p=0.039) were found to be significant by multivariate analysis. In addition, SSSwm or SDSwm were able to find undetected coronary artery disease in 54.5% (6/11) of patients with normal perfusion. We conclude that Tl-201 can be successfully applied to gated SPECT for immediate post-stress wall motion evaluation, and that reversible wall motion abnormality on adenosine stress/rest Tl-201 gated myocardial SPECT is an independent predictor of significant coronary artery disease.en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subjectAdenosine/diagnostic useen
dc.subjectCoronary Angiographyen
dc.subjectCoronary Artery Disease/physiopathology/radiography/*radionuclide imagingen
dc.subjectExercise Testen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Processing, Computer-Assisteden
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectReproducibility of Resultsen
dc.subjectSoftwareen
dc.subjectThallium Radioisotopes/diagnostic useen
dc.subject*Tomography, Emission-Computed, Single-Photonen
dc.titleEvaluation of immediate post-stress wall motion on adenosine stress/rest thallium-201 gated myocardial SPECTen
dc.typeArticleen
dc.contributor.AlternativeAuthor이원우-
dc.contributor.AlternativeAuthor박은경-
dc.contributor.AlternativeAuthor어재선-
dc.contributor.AlternativeAuthor이상우-
dc.contributor.AlternativeAuthor김철호-
dc.contributor.AlternativeAuthor소영-
dc.contributor.AlternativeAuthor이동수-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor이명철-
dc.contributor.AlternativeAuthor김상은-
dc.identifier.doi10.1007/s10554-005-9001-7-
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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