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Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians

Cited 148 time in Web of Science Cited 159 time in Scopus
Authors
Fuku, Noriyuki; Park, Kyong Soo; Yamada, Yoshiji; Nishigaki, Yutaka; Cho, Young Min; Matsuo, Hitoshi; Segawa, Tomonori; Watanabe, Sachiro; Kato, Kimihiko; Yokoi, Kiyoshi; Nozawa, Yoshinori; Lee, Hong Kyu; Tanaka, Masashi
Issue Date
2007-02-03
Publisher
Elsevier
Citation
Am J Hum Genet. 2007 Mar;80(3):407-15. Epub 2007 Jan 22.
Keywords
AdolescentAdultAgedAged, 80 and overAsian Continental Ancestry Group/*geneticsBlood GlucoseCase-Control StudiesDNA, Mitochondrial/*geneticsDiabetes Mellitus, Type 2/*genetics/metabolismFemaleGenetic Predisposition to DiseaseGenotypeHaplotypes/*geneticsHumansInsulin/secretionInsulin Resistance/*geneticsMaleMiddle AgedMitochondria/*geneticsPolymorphism, Single NucleotideQuantitative Trait Loci/genetics
Abstract
Because mitochondria play pivotal roles in both insulin secretion from the pancreatic beta cells and insulin resistance of skeletal muscles, we performed a large-scale association study to identify mitochondrial haplogroups that may confer resistance against or susceptibility to type 2 diabetes mellitus (T2DM). The study population comprised 2,906 unrelated Japanese individuals, including 1,289 patients with T2DM and 1,617 controls, and 1,365 unrelated Korean individuals, including 732 patients with T2DM and 633 controls. The genotypes for 25 polymorphisms in the coding region of the mitochondrial genome were determined, and the haplotypes were classified into 10 major haplogroups (i.e., F, B, A, N9a, M7a, M7b, G, D4a, D4b, and D5). Multivariate logistic-regression analysis with adjustment for age and sex revealed that the mitochondrial haplogroup N9a was significantly associated with resistance against T2DM (P=.0002) with an odds ratio of 0.55 (95% confidence interval 0.40-0.75). Even in the modern environment, which is often characterized by satiety and physical inactivity, this haplogroup might confer resistance against T2DM.
ISSN
0002-9297 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17273962

https://hdl.handle.net/10371/27392
DOI
https://doi.org/10.1086/512202
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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