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IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Kim, Chung Yong | - |
dc.contributor.author | Kim, Lyoung Hyo | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.date.accessioned | 2010-01-07 | - |
dc.date.available | 2010-01-07 | - |
dc.date.issued | 2006-06-06 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2006 Jul 21;346(1):38-44. Epub 2006 May 24. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16750516 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27451 | - |
dc.description.abstract | The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of hepatitis B virus (HBV) infection and the risk of hepatocellular carcinoma (HCC). A total of 1095 Korean subjects were prospectively enrolled in this case-control study. The rates of IGF2 polymorphisms were determined in each group. The IGF2+820G allele (IGF2+820G/G) and the IGF2+6815A/A genotype were strongly associated with the resolution of HBV infection (OR=0.62-0.73; P=0.001-0.03 and OR=0.71; P=0.03, respectively). Haplotype analysis showed that IGF2-haplotype5 (A-C-C-T-A-T-G) and IGF2-haplotype1 (T-C-T-T-A-C-A) were significantly associated with the clearance and persistence of HBV infection (OR=0.55-0.58, P=0.009-0.01 and OR=1.31-1.65, P=0.001-0.007, respectively). On the other hand, the IGF2+2482C/C or +820G/G genotypes were significantly associated with a higher risk of HCC (OR=1.88, 1.68; P=0.04). IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Age Factors | en |
dc.subject | Aged | en |
dc.subject | Asian Continental Ancestry Group/genetics | en |
dc.subject | Carcinoma, Hepatocellular/etiology/*genetics | en |
dc.subject | Female | en |
dc.subject | Haplotypes | en |
dc.subject | Hepatitis B virus/immunology | en |
dc.subject | Hepatitis B, Chronic/genetics/*virology | en |
dc.subject | Humans | en |
dc.subject | Insulin-Like Growth Factor II | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic/*genetics | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Prospective Studies | en |
dc.subject | Proteins/*genetics | en |
dc.title | IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 김청용 | - |
dc.contributor.AlternativeAuthor | 김령호 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.05.080 | - |
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