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Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut

Cited 76 time in Web of Science Cited 75 time in Scopus
Authors
Shen, Min; Zheng, Tongzhang; Lan, Qing; Zhang, Yawei; Zahm, Shelia H.; Wang, Sophia S.; Holford, Theodore R.; Leaderer, Brian; Yeager, Meredith; Welch, Robert; Kang, Daehee; Boyle, Peter; Zhang, Bing; Zou, Kaiyong; Zhu, Yong; Chanock, Stephen; Rothman, Nathaniel
Issue Date
2006-06-02
Publisher
Springer Verlag
Citation
Hum Genet. 2006 Jul;119(6):659-68. Epub 2006 Apr 26.
Keywords
AdultAgedCase-Control StudiesConnecticutDNA Repair/*geneticsFemale*Genetic Predisposition to DiseaseHumansLymphoma, Non-Hodgkin/*geneticsMiddle Aged*Polymorphism, GeneticRisk Factors
Abstract
Several hereditary syndromes characterized by defective DNA repair are associated with high risk of non-Hodgkin lymphoma (NHL). To explore whether common polymorphisms in DNA repair genes affect risk of NHL in the general population, we evaluated the association between single nucleotide polymorphisms (SNPs) in DNA repair genes and risk of NHL in a population-based case-control study among women in Connecticut. A total of 518 NHL cases and 597 controls recruited into the study provided a biologic sample. Thirty-two SNPs in 18 genes involved in several DNA repair pathways were genotyped. Genotype data were analyzed by unconditional logistic regression adjusting for age and race. SNPs in four genes (ERCC5, ERCC2, WRN, and BRCA1) were associated with altered risk of NHL and diffuse large B-cell lymphoma (DLBCL), the major B cell subtype. In particular, ERCC5 Asp1104His was associated with increased risk of NHL overall (OR: 1.46; 95% CI: 1.13-1.88; P=0.004), DLBCL (OR: 1.44; 95% CI: 0.99-2.09; P=0.058), and also T cell lymphoma. WRN Cys1367Arg was associated with decreased risk of NHL overall (OR: 0.71; 95% CI: 0.56-0.91; P=0.007) and DLBCL (OR: 0.66; 95% CI: 0.45-0.95; P=0.024), as well as follicular and marginal zone lymphomas. Genetic polymorphisms in DNA repair genes, particularly ERCC5 and WRN, may play a role in the pathogenesis of NHL, especially for DLBCL. Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies.
ISSN
0340-6717 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16738949

https://hdl.handle.net/10371/27802
DOI
https://doi.org/10.1007/s00439-006-0177-2
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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