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A novel compound, maltolyl p-coumarate, attenuates cognitive deficits and shows neuroprotective effects in vitro and in vivo dementia models
DC Field | Value | Language |
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dc.contributor.author | Shin, Ki Young | - |
dc.contributor.author | Lee, Geon Ho | - |
dc.contributor.author | Park, Cheol Hyoung | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Park, Soo-Hyun | - |
dc.contributor.author | Kim, Seonghan | - |
dc.contributor.author | Kim, Hye-Sun | - |
dc.contributor.author | Lee, Kwan-Sun | - |
dc.contributor.author | Won, Beom Young | - |
dc.contributor.author | Lee, Hyung Gun | - |
dc.contributor.author | Choi, Jin-Ho | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.date.accessioned | 2010-01-07T02:10:49Z | - |
dc.date.available | 2010-01-07T02:10:49Z | - |
dc.date.issued | 2007-06-30 | - |
dc.identifier.citation | J Neurosci Res. 2007 Aug 15;85(11):2500-11. | en |
dc.identifier.issn | 0360-4012 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17600377 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27836 | - |
dc.description.abstract | To develop a novel and effective drug that could enhance cognitive function and neuroprotection, we newly synthesized maltolyl p-coumarate by the esterification of maltol and p-coumaric acid. In the present study, we investigated whether maltolyl p-coumarate could improve cognitive decline in scopolamine-injected rats and in amyloid beta peptide(1-42)-infused rats. Maltolyl p-coumarate was found to attenuate cognitive deficits in both rat models using passive avoidance test and to reduce apoptotic cell death observed in the hippocampus of the amyloid beta peptide(1-42)-infused rats. We also examined the neuroprotective effects of maltolyl p-coumarate in vitro using SH-SY5Y cells. Cells were pretreated with maltolyl p-coumarate, before exposed to amyloid beta peptide(1-42), glutamate or H2O2. We found that maltolyl p-coumarate significantly decreased apoptotic cell death and reduced reactive oxygen species, cytochrome c release, and caspase 3 activation. Taking these in vitro and in vivo results together, our study suggests that maltolyl p-coumarate is a potentially effective candidate against Alzheimer's disease that is characterized by wide spread neuronal death and progressive decline of cognitive function. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Amyloid beta-Protein/toxicity | en |
dc.subject | Animals | en |
dc.subject | Apoptosis/drug effects | en |
dc.subject | Blotting, Western | en |
dc.subject | Caspase 3/drug effects | en |
dc.subject | Cognition/drug effects | en |
dc.subject | Coumaric Acids/*pharmacology | en |
dc.subject | Cytochromes c/drug effects | en |
dc.subject | Dementia/chemically induced/*drug therapy | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Enzyme Activation/drug effects | en |
dc.subject | In Situ Nick-End Labeling | en |
dc.subject | Muscarinic Antagonists/toxicity | en |
dc.subject | Neuroprotective Agents/chemistry/*pharmacology | en |
dc.subject | Pyrones/*pharmacology | en |
dc.subject | Rats | en |
dc.subject | Rats, Wistar | en |
dc.subject | Reactive Oxygen Species/metabolism | en |
dc.subject | Scopolamine/toxicity | en |
dc.title | A novel compound, maltolyl p-coumarate, attenuates cognitive deficits and shows neuroprotective effects in vitro and in vivo dementia models | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신기영 | - |
dc.contributor.AlternativeAuthor | 이건호 | - |
dc.contributor.AlternativeAuthor | 박철형 | - |
dc.contributor.AlternativeAuthor | 김희진 | - |
dc.contributor.AlternativeAuthor | 박수현 | - |
dc.contributor.AlternativeAuthor | 김성한 | - |
dc.contributor.AlternativeAuthor | 김혜선 | - |
dc.contributor.AlternativeAuthor | 이관선 | - |
dc.contributor.AlternativeAuthor | 원범영 | - |
dc.contributor.AlternativeAuthor | 이형근 | - |
dc.contributor.AlternativeAuthor | 최진호 | - |
dc.contributor.AlternativeAuthor | 서유헌 | - |
dc.identifier.doi | 10.1002/jnr.21397 | - |
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