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Gray matter volume reduction in obsessive-compulsive disorder with schizotypal personality trait

Cited 14 time in Web of Science Cited 20 time in Scopus
Authors
Lee, Kyung Jin; Shin, Yong Wook; Wee, Hwee; Kim, Young Youn; Kwon, Jun Soo
Issue Date
2006-05-02
Publisher
Elsevier
Citation
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1146-9. Epub 2006 May 2.
Keywords
AdultBrain/*pathologyData Interpretation, StatisticalFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleObsessive-Compulsive Disorder/complications/*pathology/psychologyPsychiatric Status Rating ScalesSchizotypal Personality Disorder/complications/*pathology/psychology
Abstract
OBJECTIVES: Obsessive-compulsive disorder (OCD) with schizotypal personality trait (SPT) and OCD without SPT demonstrated differences in cognitive dysfunction and treatment response. This study aimed to investigate whether brain volume differs between OCD with SPT and OCD without SPT. METHODS: OCD with SPT (n=20), OCD without SPT (n=47), healthy comparison subjects (n=83) and schizophrenic patients (n=59) participated in this study. We assessed brain volume such as gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) using magnetic resonance imaging. The imaging data sets were filtered using anisotropic diffusion methods to improve the signal to noise ratio. The semi-automated region-growing method was used to remove images of tissues exterior to the brain. The fuzzy C-means algorithm was used to segment the extracted brain images into gray matter, white matter and cerebrospinal fluid. RESULTS: OCD with SPT (p=0.048) and Schizophrenic patients (p<0.001) demonstrated a significant GM volume reduction compared to healthy controls. OCD without SPT revealed no significant GM volume reduction compared to healthy controls (p=0.504). CONCLUSION: This study suggests that OCD with SPT could be distinguished as a distinct subtype of OCD, based on observations of gray matter volume.
ISSN
0278-5846 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBR-4JVSVN6-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=683473c5da7165d44b4c3688817a9390

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16647175

http://hdl.handle.net/10371/27860
DOI
https://doi.org/10.1016/j.pnpbp.2006.03.022
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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