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8-oxo-7,8-dihydroguanosine triphosphate(8-oxoGTP) down-regulates respiratory burst of neutrophils by antagonizing GTP toward Rac, a small GTP binding protein
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hee Joon | - |
dc.contributor.author | Yoon, Sun-Hee | - |
dc.contributor.author | Ryu, Hyun-Ok | - |
dc.contributor.author | Yoon, Byung-Hak | - |
dc.contributor.author | Choi, Seongwon | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Chung, Myung-Hee | - |
dc.date.accessioned | 2010-01-07T02:23:50Z | - |
dc.date.available | 2010-01-07T02:23:50Z | - |
dc.date.issued | 2007-05-23 | - |
dc.identifier.citation | Free Radic Res. 2007 Jun;41(6):655-62. | en |
dc.identifier.issn | 1071-5762 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17516238 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27862 | - |
dc.description.abstract | 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) has been regarded simply as a oxidative mutagenic byproduct. The results obtained in this study imply that it may act as a down-regulator of respiratory burst of neutrophils. Human neutrophils treated with PMA produced superoxides and at the same time, the cytosol of these cells was intensely immunostained by 8-oxo-7,8-dihydroguanosine(8-oxoG) antibody, indicating that 8-oxoG-containing chemical species including 8-oxoGTP are produced. Human neutrophil lysates treated with PMA also produced superoxides, which was stimulated by GTPgammaS but inhibited by 8-oxoGTPgammaS. Moreover, 8-oxoGTPgammaS suppressed the stimulatory action of GTPgammaS. Likewise, GTPgammaS stimulated Rac activity in neutrophil lysates but 8-oxoGTPgammaS and GDP inhibited it. The inhibitory effect of GDP was one tenth that of 8-oxoGTPgammaS. Here again, 8-oxoGTPgammaS also suppressed the stimulatory action of GTPgammaS on Rac activity. These results imply the possibility that 8-oxoGTP is formed during respiratory burst of neutrophils and limits neutrophil production of superoxides by antagonizing GTP toward Rac. | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | Adult | en |
dc.subject | Carcinogens/pharmacology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Deoxyguanine Nucleotides/immunology/*pharmacology | en |
dc.subject | Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology | en |
dc.subject | Guanosine Diphosphate/metabolism | en |
dc.subject | Humans | en |
dc.subject | NADPH Oxidase/metabolism | en |
dc.subject | Neutrophils/*drug effects/metabolism | en |
dc.subject | Respiratory Burst/*drug effects | en |
dc.subject | Superoxides/*metabolism | en |
dc.subject | Tetradecanoylphorbol Acetate/pharmacology | en |
dc.subject | rac GTP-Binding Proteins/*metabolism | en |
dc.title | 8-oxo-7,8-dihydroguanosine triphosphate(8-oxoGTP) down-regulates respiratory burst of neutrophils by antagonizing GTP toward Rac, a small GTP binding protein | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김희준 | - |
dc.contributor.AlternativeAuthor | 윤선희 | - |
dc.contributor.AlternativeAuthor | 류현옥 | - |
dc.contributor.AlternativeAuthor | 윤병학 | - |
dc.contributor.AlternativeAuthor | 최성원 | - |
dc.contributor.AlternativeAuthor | 예상규 | - |
dc.contributor.AlternativeAuthor | 정명희 | - |
dc.identifier.doi | 10.1080/10715760701250270 | - |
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