Browse

Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk

Cited 102 time in Web of Science Cited 106 time in Scopus
Authors
Lee, Kyoung-Mu; Choi, Ji-Yeob; Kang, Changwon; Kang, Changsoo Paul; Park, Sue Kyung; Cho, Hyunmi; Cho, Dae-Yeon; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Park, Chung-Gyu; Wei, Qingyi; Kang, Daehee
Issue Date
2005-06-17
Publisher
American Association for Cancer Research
Citation
Clin Cancer Res. 2005 Jun 15;11(12):4620-6.
Keywords
Adaptor Proteins, Signal TransducingAdultBreast Neoplasms/genetics/metabolism/*pathologyCarrier ProteinsCase-Control StudiesDNA Repair/*geneticsDNA-Binding Proteins/geneticsEndonucleases/geneticsFemaleGenotypeHumansImmunohistochemistryMiddle AgedNeoplasm Proteins/geneticsNuclear Proteins/genetics*Polymorphism, GeneticRad52 DNA Repair and Recombination ProteinReceptors, Estrogen/*analysisReceptors, Progesterone/*analysisRisk FactorsSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Abstract
PURPOSE: Genetic polymorphisms of DNA repair genes seem to determine the DNA repair capacity, which in turn may affect the risk of breast cancer. To evaluate the role of genetic polymorphisms of DNA repair genes in breast cancer, we conducted a hospital-based case-control study of Korean women. EXPERIMENTAL DESIGN: We included 872 incident breast cancer cases and 671 controls recruited from several teaching hospitals in Seoul from 1995 to 2002. Twelve loci of selected DNA repair genes were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (XRCC2 Arg188His, XRCC4 921G > T, XRCC6 1796G > T, LIG4 1977T/C, RAD51 135G > C, 172G > T, RAD52 2259C > T, LIG1 551A > C, ERCC1 8092A > C, 354C > T, hMLH1 -93G > A, and Ile219Val). RESULTS: We found that the RAD52 2259 CT or TT, hMLH1 -93 GG, and ERCC1 8092 AA genotypes were associated with breast cancer risk after adjustment for known risk factors [odds ratio (OR), 1.33; 95% confidence interval (95% CI), 1.02-1.75; OR, 1.31; 95% CI, 0.99-1.74; and OR, 0.58; 95% CI, 0.38-0.89, respectively]. When Bonferroni's method was used to correct for multiple comparisons for nine polymorphisms with P = 0.005, all of these associations were not significant. However, the effects of RAD52 2259 CT or TT and ERCC1 354 CT or TT genotypes were more evident for the estrogen/progesterone receptor-negative cases (OR, 2.03; 95% CI, 1.24-3.34 and OR, 1.99; 95% CI, 1.35-2.94, respectively). CONCLUSION: Our findings suggest that genetic polymorphisms of RAD52, ERCC1, and hMLH1 may be associated with breast cancer risk in Korean women.
ISSN
1078-0432 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15958648

https://hdl.handle.net/10371/27896
DOI
https://doi.org/10.1158/1078-0432.CCR-04-2534
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse