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CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea

Cited 50 time in Web of Science Cited 58 time in Scopus
Authors

Gwack, J.; Shin, A.; Kim, C. S.; Ko, K. P.; Kim, Y.; Jun, J. K.; Bae, J.; Park, S. K.; Hong, Y. C.; Kang, D.; Chang, S. H.; Shin, H. R.; Yoo, K. Y.

Issue Date
2006-08-16
Publisher
Nature Publishing Group
Citation
Br J Cancer. 2006 Sep 4;95(5):639-41. Epub 2006 Aug 8.
Keywords
AgedAlcohol DrinkingAntigens, BacterialBacterial ProteinsCase-Control StudiesFemaleHelicobacter Infections/*complications/epidemiologyHelicobacter pylori/genetics/*isolation & purification/pathogenicityHumansKorea/epidemiologyMaleMiddle AgedRisk FactorsSmokingStomach Neoplasms/*epidemiology/*microbiologyVirulence
Abstract
In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14).
ISSN
0007-0920 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16909137

https://hdl.handle.net/10371/27962
DOI
https://doi.org/10.1038/sj.bjc.6603309
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