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Early engraftment kinetics of two units cord blood transplantation

Cited 29 time in Web of Science Cited 29 time in Scopus
Authors
Kang, H J; Kho, S H; Jang, M K; Lee, S H; Shin, H Y; Ahn, H S
Issue Date
2006-06-21
Publisher
Nature Publishing Group
Citation
Bone Marrow Transplant. 2006 Aug;38(3):197-201. Epub 2006 Jun 19.
Keywords
Acute DiseaseAdolescentAnemia, Aplastic/pathology/*therapyChildCord Blood Stem Cell Transplantation/*methodsFemaleGraft Survival/*physiologyHumansLeukemia/pathology/*therapyMaleTransplantation Conditioning/methods
Abstract
Cord blood transplantation (CBT) is a promising alternative means of allogeneic stem cell transplantation. However, limited cell doses may compromise outcome. To enhance engraftment, CBT has been conducted using two units with promising results. However, little is known about the mechanism of engraftment. Here, we analyzed the early engraftment kinetics of eight patients given two unit umbilical CBT. Early engraftment kinetics revealed dominancy of one of two units from the day of engraftment (absolute neutrophil count > 0.5 x 10(9)/l). The median value of percentage of the predominant unit by chimerism analysis at the time of engraftment was 88% (60-100%). Two units CBT was found to be a safe, effective and promising alternative treatment option with good engraftment potential. Dominancy occurred early after CBT and is probably influenced by multiple factors.
ISSN
0268-3369 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16785866

http://hdl.handle.net/10371/28038
DOI
https://doi.org/10.1038/sj.bmt.1705423
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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