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Restoration of left ventricular synchronous contraction after acute myocardial infarction by stem cell therapy: new insights into the therapeutic implication of stem cell therapy for acute myocardial infarction

Cited 20 time in Web of Science Cited 23 time in Scopus
Authors
Chang, S-A; Kim, H-K; Lee, H-Y; Choi, S-Y; Koo, B-K; Kim, Y-J; Sohn, D-W; Oh, B-H; Park, Y-B; Choi, Y-S; Kang, H-J; Kim, H-S
Issue Date
2008
Publisher
BMJ Publishing Group
Citation
Heart 2008;94:995-1001
Keywords
Echocardiography, Doppler/methodsExercise TestExercise ToleranceFemaleHematopoietic Stem Cell Mobilization/methodsHumansMagnetic Resonance Imaging/methodsMaleMiddle AgedMyocardial ContractionMyocardial Infarction/complications/physiopathology/*therapyPeripheral Blood Stem Cell Transplantation/*methodsProspective StudiesStroke VolumeTreatment OutcomeVentricular Dysfunction, Left/diagnosis/etiology/physiopathology/*therapy
Abstract
OBJECTIVE: To evaluate the effects of stem cell therapy on restoration of the left ventricular (LV) synchronous contraction in patients with acute myocardial infarction (AMI). METHODS: 40 patients with AMI who underwent successful coronary revascularisation were randomly allocated to the cell infusion or the control group. Evaluations were performed with echocardiographic tissue synchronisation imaging to determine LV dyssynchrony and with cardiac magnetic resonance imaging to estimate LV ejection fraction (LVEF) at baseline and at 6 months. To quantify the severity of systolic LV dyssynchrony, the standard deviations of time to peak systolic velocity of the 12 LV segments (Ts-SD) were calculated. RESULTS: At 6 months, greater improvements of Ts-SD (DeltaTs-SD: -45.0 (40.2) vs 5.0 (39.9) ms, p<0.001) and LVEF (DeltaLVEF: 6.8% (9.1%) vs -0.2% (6.9%), p = 0.015) relative to the corresponding baseline values were observed in the cell infusion group than in the control group. By multivariate analysis, DeltaTs-SD and baseline LVEF emerged as the independent determinants of LVEF improvement and cell infusion, and baseline Ts-SD as the determinant of DeltaTs-SD improvement. Maximal exercise capacity measured by symptom-limited treadmill testing correlated well with Ts-SD but not with LVEF at 6 months of follow-up. CONCLUSION: Stem cell therapy had a favourable effect on the restoration of LV synchronous contraction in patients with AMI.
ISSN
1468-201X (Electronic)
Language
English
URI
http://heart.bmj.com/cgi/content/abstract/94/8/995

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17974698

https://hdl.handle.net/10371/28199
DOI
https://doi.org/10.1136/hrt.2007.124701
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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