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A common coding variant in CASP8 is associated with breast cancer risk

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dc.contributor.authorCox, Angela-
dc.contributor.authorDunning, Alison M-
dc.contributor.authorGarcia-Closas, Montserrat-
dc.contributor.authorBalasubramanian, Sabapathy-
dc.contributor.authorReed, Malcolm W R-
dc.contributor.authorPooley, Karen A-
dc.contributor.authorScollen, Serena-
dc.contributor.authorBaynes, Caroline-
dc.contributor.authorPonder, Bruce A J-
dc.contributor.authorChanock, Stephen-
dc.contributor.authorLissowska, Jolanta-
dc.contributor.authorBrinton, Louise-
dc.contributor.authorPeplonska, Beata-
dc.contributor.authorSouthey, Melissa C-
dc.contributor.authorHopper, John L-
dc.contributor.authorMcCredie, Margaret R E-
dc.contributor.authorGiles, Graham G-
dc.contributor.authorFletcher, Olivia-
dc.contributor.authorJohnson, Nichola-
dc.contributor.authordos Santos Silva, Isabel-
dc.contributor.authorGibson, Lorna-
dc.contributor.authorBojesen, Stig E-
dc.contributor.authorNordestgaard, Borge G-
dc.contributor.authorAxelsson, Christen K-
dc.contributor.authorTorres, Diana-
dc.contributor.authorHamann, Ute-
dc.contributor.authorJustenhoven, Christina-
dc.contributor.authorBrauch, Hiltrud-
dc.contributor.authorChang-Claude, Jenny-
dc.contributor.authorKropp, Silke-
dc.contributor.authorRisch, Angela-
dc.contributor.authorWang-Gohrke, Shan-
dc.contributor.authorSchurmann, Peter-
dc.contributor.authorBogdanova, Natalia-
dc.contributor.authorDork, Thilo-
dc.contributor.authorFagerholm, Rainer-
dc.contributor.authorAaltonen, Kirsimari-
dc.contributor.authorBlomqvist, Carl-
dc.contributor.authorNevanlinna, Heli-
dc.contributor.authorSeal, Sheila-
dc.contributor.authorRenwick, Anthony-
dc.contributor.authorStratton, Michael R-
dc.contributor.authorRahman, Nazneen-
dc.contributor.authorSangrajrang, Suleeporn-
dc.contributor.authorHughes, David-
dc.contributor.authorOdefrey, Fabrice-
dc.contributor.authorBrennan, Paul-
dc.contributor.authorSpurdle, Amanda B-
dc.contributor.authorChenevix-Trench, Georgia-
dc.contributor.authorBeesley, Jonathan-
dc.contributor.authorMannermaa, Arto-
dc.contributor.authorHartikainen, Jaana-
dc.contributor.authorKataja, Vesa-
dc.contributor.authorKosma, Veli-Matti-
dc.contributor.authorCouch, Fergus J-
dc.contributor.authorOlson, Janet E-
dc.contributor.authorGoode, Ellen L-
dc.contributor.authorBroeks, Annegien-
dc.contributor.authorSchmidt, Marjanka K-
dc.contributor.authorHogervorst, Frans B L-
dc.contributor.authorVan't Veer, Laura J-
dc.contributor.authorKang, Daehee-
dc.contributor.authorYoo, Keun-Young-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorAhn, Sei-Hyun-
dc.contributor.authorWedren, Sara-
dc.contributor.authorHall, Per-
dc.contributor.authorLow, Yen-Ling-
dc.contributor.authorLiu, Jianjun-
dc.contributor.authorMilne, Roger L-
dc.contributor.authorRibas, Gloria-
dc.contributor.authorGonzalez-Neira, Anna-
dc.contributor.authorBenitez, Javier-
dc.contributor.authorSigurdson, Alice J-
dc.contributor.authorStredrick, Denise L-
dc.contributor.authorAlexander, Bruce H-
dc.contributor.authorStruewing, Jeffery P-
dc.contributor.authorPharoah, Paul D P-
dc.contributor.authorEaston, Douglas F-
dc.date.accessioned2010-01-07T05:03:03Z-
dc.date.available2010-01-07T05:03:03Z-
dc.date.issued2007-02-13-
dc.identifier.citationNat Genet. 2007 Mar;39(3):352-8. Epub 2007 Feb 11.en
dc.identifier.issn1061-4036 (Print)-
dc.identifier.urihttp://www.nature.com/ng/journal/v39/n3/abs/ng1981.html-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17293864-
dc.identifier.urihttps://hdl.handle.net/10371/28201-
dc.description.abstractThe Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.en
dc.language.isoen-
dc.publisherNature Publishing Groupen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast Neoplasms/*geneticsen
dc.subjectCase-Control Studiesen
dc.subjectCaspase 8/*geneticsen
dc.subjectCohort Studiesen
dc.subjectFemaleen
dc.subject*Genetic Predisposition to Diseaseen
dc.subjectGenetic Variationen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectRisk Factorsen
dc.titleA common coding variant in CASP8 is associated with breast cancer risken
dc.typeArticleen
dc.contributor.AlternativeAuthor강대희-
dc.contributor.AlternativeAuthor유건영-
dc.contributor.AlternativeAuthor노동영-
dc.contributor.AlternativeAuthor안세현-
dc.identifier.doi10.1038/ng1981-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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