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Hematopoietic malignancies associated with increased Stat5 and Bcl-x(L) expressions in Ink4a/Arf-deficient mice

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Sung, Young Hoon; Park, Junghwan; Choi, Bongkun; Kim, Jaehong; Cheong, Cheolho; Choi, Yoon Sik; Yang, Eun Young; Lee, Minjae; Han, Jin Soo; Park, Sang Chul; Han, Tae-Hee; Kim, Tae Jin; Song, Jaewhan; Rhee, Kunsoo; Lee, Han-Woong
Issue Date
2005-05-13
Publisher
Elsevier
Citation
Mech Ageing Dev. 2005 Jun-Jul;126(6-7):732-9.
Keywords
AnimalsCyclin-Dependent Kinase Inhibitor p16/*deficiencyDNA-Binding Proteins/*biosynthesisGene Expression Regulation, Neoplastic/geneticsHematologic Neoplasms/genetics/*metabolism*HematopoiesisMiceMice, KnockoutMilk Proteins/*biosynthesisProto-Oncogene Proteins c-bcl-2/*biosynthesisSTAT5 Transcription FactorSignal Transduction/geneticsTrans-Activators/*biosynthesisTumor Suppressor Protein p14ARF/*deficiencybcl-X Protein
Abstract
The INK4a/ARF locus, which encodes the two distinct proteins p16(INK4a) and p14(ARF), is frequently altered in various hematological malignancies as well as in other types of cancers in humans. In this study, we surveyed tumors that had spontaneously developed in Ink4a/Arf-deficient mice with an inbred FVB/NJ genetic background. We found that an Ink4a/Arf-deficiency exerted more severe effects on the induction of hematopoietic malignancies in mice with an inbred FVB/NJ genetic background than in mice with a mixed genetic background. We also provided the evidence that this prevalence of hematopoietic malignancies in Ink4a/Arf-deficient mice is associated with the upregulated expressions of Stat5 and its transcriptional target, Bcl-x(L), both of which are involved in the regulation of hematopoiesis. These results suggest a possible implication of the Ink4a/Arf locus in the control of hematopoietic pathways by negatively regulating the Stat5-signalling pathways.
ISSN
0047-6374 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15888328

https://hdl.handle.net/10371/28382
DOI
https://doi.org/10.1016/j.mad.2005.01.007
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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