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Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits

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dc.contributor.authorPark, Kyung Sun-
dc.contributor.authorLee, Hyang Ae-
dc.contributor.authorEarm, Kee Hyun-
dc.contributor.authorKo, Jae Hong-
dc.contributor.authorEarm, Yung E-
dc.contributor.authorKim, Sung Joon-
dc.date.accessioned2010-01-07T06:46:49Z-
dc.date.available2010-01-07T06:46:49Z-
dc.date.issued2006-05-31-
dc.identifier.citationJ Vasc Res. 2006;43(4):347-54. Epub 2006 May 29.en
dc.identifier.issn1018-1172 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16733370-
dc.identifier.urihttps://hdl.handle.net/10371/28483-
dc.description.abstractThe mechanosensitive nonselective cation channel (NSC(MS)) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSC(MS) in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-attached condition, a negative pressure via patch pipettes commonly activated NSC(MS) with weak voltage dependence. The threshold pressure for activation was lower, and the density of NSC(MS) was higher in the pulmonary than the systemic arteries. When the pulmonary arteries were divided into small-diameter (outer diameter, OD < 0.5 mm) and large-diameter (OD > 1.5 mm) arteries, the low threshold and high density of NSC(MS) were observed only in small-diameter ones. No such difference was observed between the small- and large-diameter coronary arteries. The higher stretch sensitivity and denser functional expression of NSC(MS) in small pulmonary arteries might suggest an adaptive tuning for the relatively low pulmonary blood pressure in vivo.en
dc.language.isoen-
dc.publisherKargeren
dc.subjectAnimalsen
dc.subject*Cationsen
dc.subjectCoronary Vessels/anatomy & histology/*physiologyen
dc.subjectIon Channel Gatingen
dc.subjectIon Channels/*physiologyen
dc.subjectMechanoreceptors/*physiologyen
dc.subjectMechanotransduction, Cellularen
dc.subjectMembrane Potentialsen
dc.subjectMesenteric Arteries/anatomy & histology/*physiologyen
dc.subjectMuscle Contractionen
dc.subjectMyocytes, Smooth Muscle/physiologyen
dc.subjectPatch-Clamp Techniquesen
dc.subjectPressureen
dc.subjectPulmonary Artery/anatomy & histology/*physiologyen
dc.subjectRabbitsen
dc.titleDifferential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbitsen
dc.typeArticleen
dc.contributor.AlternativeAuthor박경선-
dc.contributor.AlternativeAuthor이향애-
dc.contributor.AlternativeAuthor엄기현-
dc.contributor.AlternativeAuthor고재홍-
dc.contributor.AlternativeAuthor엄융의-
dc.contributor.AlternativeAuthor김성준-
dc.identifier.doi10.1159/000093607-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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