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Autologous peripheral blood stem cell transplantation in children with non-Hodgkin's lymphoma: A report from the Korean society of pediatric hematology-oncology
DC Field | Value | Language |
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dc.contributor.author | Won, Sung Chul | - |
dc.contributor.author | Han, Jung Woo | - |
dc.contributor.author | Kwon, Seung Yeon | - |
dc.contributor.author | Shin, Hee-Young | - |
dc.contributor.author | Ahn, Hyo-Seop | - |
dc.contributor.author | Hwang, Tae Ju | - |
dc.contributor.author | Yang, Woo Ick | - |
dc.contributor.author | Lyu, Chuhl Joo | - |
dc.date.accessioned | 2010-01-08T05:19:28Z | - |
dc.date.available | 2010-01-08T05:19:28Z | - |
dc.date.issued | 2006-08-26 | - |
dc.identifier.citation | Ann Hematol. 2006 Nov;85(11):787-94. Epub 2006 Aug 24. | en |
dc.identifier.issn | 0939-5555 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16932891 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28900 | - |
dc.description.abstract | Recent development of stratified chemotherapeutic regimens has rapidly improved the survival rate of non-Hodgkin's lymphoma (NHL) of childhood. Despite these improvements, the outcome for children with recurrent or refractory NHL remains dismal. We explored the use of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (HDC/PBSCT) for children with either refractory or recurrent NHL, and we evaluated various factors influencing outcome of HDC/PBSCT. Thirty-three patients underwent HDC/PBSCT in 11 institutes were enrolled. All patients had refractory or recurrent NHL. Sex, stage at diagnosis, histologic subtype (lymphoblastic, Burkitt's, and large-cell lymphoma), LDH level at diagnosis, disease status at transplantation, and preparative regimens for HDC/PBSCT were explored. In regard to the patients, six had Burkitt's lymphoma, 13 had lymphoblastic lymphoma, and 14 had large-cell lymphoma. The 2-year event-free survival (EFS) was 59.1+/-9.3%. The EFS for Burkitt's, lymphoblastic, and large-cell lymphoma was 66.7+/-27.2, 50.5+/-14.8, and 82.1+/-11.7%, respectively. In comparison with lymphoblastic and non-lymphoblastic lymphoma, the relative risk for lymphoblastic lymphoma was higher than the others (P = 0.037). EFS between anaplastic large-cell and diffuse large-cell lymphoma was 100 and 55.6+/-24.9%, respectively (P = 0.106). Status at transplantation was the most predictive factor for the survival after HDC/PBSCT (EFS for CR 70.8+/-9.5% vs non-CR 20.0+/-17.9%, P = 0.008). Transplantation-related complications were minimal, and infection was the most prevalent complication. HDC/PBSCT is considered applicable to recurrent or refractory pediatric NHL patients safely and it could replace conventional chemotherapy. In this study, children with CR status at the time of HDC/PBSCT showed higher survival rate. However, refractory or recurrent lymphoblastic lymphoma patients showed dismal results. Therefore, new therapeutic modalities may be needed for this group of NHL patients. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adolescent | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Korea | en |
dc.subject | Lymphoma, Non-Hodgkin/mortality/*therapy | en |
dc.subject | Male | en |
dc.subject | Retrospective Studies | en |
dc.subject | Salvage Therapy | en |
dc.subject | Survival | en |
dc.subject | Survival Analysis | en |
dc.subject | Transplantation, Autologous | en |
dc.subject | Treatment Outcome | en |
dc.subject | Peripheral Blood Stem Cell Transplantation | - |
dc.title | Autologous peripheral blood stem cell transplantation in children with non-Hodgkin's lymphoma: A report from the Korean society of pediatric hematology-oncology | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 원성철 | - |
dc.contributor.AlternativeAuthor | 한정우 | - |
dc.contributor.AlternativeAuthor | 권승연 | - |
dc.contributor.AlternativeAuthor | 신희영 | - |
dc.contributor.AlternativeAuthor | 안효섭 | - |
dc.contributor.AlternativeAuthor | 황태주 | - |
dc.contributor.AlternativeAuthor | 양우익 | - |
dc.contributor.AlternativeAuthor | 유철주 | - |
dc.identifier.doi | 10.1007/s00277-006-0169-2 | - |
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