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Recombinant urate oxidase (Rasburicase) for the treatment of hyperuricemia in pediatric patients with hematologic malignancies: Results of a compassionate prospective multicenter study in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Park, Eun Sil | - |
dc.contributor.author | Choi, Hyoung Soo | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Chung, Nak Gyun | - |
dc.contributor.author | Kim, Hack Ki | - |
dc.contributor.author | Kim, So Youn | - |
dc.contributor.author | Kook, Hoon | - |
dc.contributor.author | Hwang, Tai Ju | - |
dc.contributor.author | Lee, Kwang Chul | - |
dc.contributor.author | Lee, Sun Min | - |
dc.contributor.author | Lee, Kun Soo | - |
dc.contributor.author | Yoo, Keon Hee | - |
dc.contributor.author | Koo, Hong Hoe | - |
dc.contributor.author | Lee, Mee Jung | - |
dc.contributor.author | Seo, Jong Jin | - |
dc.contributor.author | Moon, Hyung Nam | - |
dc.contributor.author | Ghim, Thad | - |
dc.contributor.author | Lyu, Chuhl Joo | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Choi, Yong Mook | - |
dc.date.accessioned | 2010-01-08T05:20:24Z | - |
dc.date.available | 2010-01-08T05:20:24Z | - |
dc.date.issued | 2005-08-27 | - |
dc.identifier.citation | Pediatr Blood Cancer. 2006 Apr;46(4):439-45. | en |
dc.identifier.issn | 1545-5009 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16123985 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28902 | - |
dc.description.abstract | BACKGROUND: Hyperuricemia accompanying tumor lysis syndrome is a serious complication in neoplasia with rapid proliferation and destruction. To confirm the efficacy of recombinant urate oxidase (rasburicase) and its safety profile, a phase IV compassionate use prospective study was performed in Korean pediatric patients with hematologic malignancies. PROCEDURE: Rasburicase was administered at 0.2 mg/kg/day once daily for 3-5 days (twice daily allowed during the first 72 hr) by intravenous route for hyperuricemia (uric acid > 7.5 mg/dl). The study period was 5 weeks and consisted of a baseline assessment within 48 hr before the administration of rasburicase, 3-5 days of assessment during treatment and a follow-up assessment at 4 weeks after its final administration. RESULTS: The uric acid endpoint (< or =7.0 mg/dl) was reached in 97.3% (36/37) of the patients and uric acid levels were significantly reduced in all patients (P < 0.001). Drug related toxicities were mild and reversible without any grade 4 or serious adverse event associated with rasburicase. CONCLUSION: This study confirms that rasburicase is a safe and effective agent for the treatment of hyperuricemia associated with hematologic malignancies in pediatric patients. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adolescent | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Drug Administration Schedule | en |
dc.subject | Female | en |
dc.subject | Hematologic Neoplasms/*complications | en |
dc.subject | Humans | en |
dc.subject | Hyperuricemia/*complications/*drug therapy | en |
dc.subject | Infant | en |
dc.subject | Infant, Newborn | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Prospective Studies | en |
dc.subject | Recombinant Proteins/administration & dosage/therapeutic use | en |
dc.subject | Renal Dialysis | en |
dc.subject | Treatment Outcome | en |
dc.subject | Urate Oxidase/administration & dosage/adverse effects/*therapeutic use | en |
dc.subject | Uric Acid/blood | en |
dc.title | Recombinant urate oxidase (Rasburicase) for the treatment of hyperuricemia in pediatric patients with hematologic malignancies: Results of a compassionate prospective multicenter study in Korea | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신희영 | - |
dc.contributor.AlternativeAuthor | 강형진 | - |
dc.contributor.AlternativeAuthor | 박은실 | - |
dc.contributor.AlternativeAuthor | 최형수 | - |
dc.contributor.AlternativeAuthor | 안효섭 | - |
dc.contributor.AlternativeAuthor | 김선영 | - |
dc.contributor.AlternativeAuthor | 정낙균 | - |
dc.contributor.AlternativeAuthor | 김학기 | - |
dc.contributor.AlternativeAuthor | 김소연 | - |
dc.contributor.AlternativeAuthor | 국훈 | - |
dc.contributor.AlternativeAuthor | 황태주 | - |
dc.contributor.AlternativeAuthor | 이광철 | - |
dc.contributor.AlternativeAuthor | 이선민 | - |
dc.contributor.AlternativeAuthor | 이건수 | - |
dc.contributor.AlternativeAuthor | 유건희 | - |
dc.contributor.AlternativeAuthor | 구홍회 | - |
dc.contributor.AlternativeAuthor | 이미정 | - |
dc.contributor.AlternativeAuthor | 서종진 | - |
dc.contributor.AlternativeAuthor | 문형남 | - |
dc.contributor.AlternativeAuthor | 유철주 | - |
dc.contributor.AlternativeAuthor | 이원식 | - |
dc.contributor.AlternativeAuthor | 최용묵 | - |
dc.identifier.doi | 10.1002/pbc.20555 | - |
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