S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients
- Shin, Yong-Wook; Kwon, Jun Soo; Ha, Tae Hyon; Park, Hae-Jeong; Kim, Dae Jin; Hong, Soon Beom; Moon, Won-Jin; Lee, Jong Min; Kim, In Young; Kim, Sun I; Chung, Eun Chul
- Issue Date
- Neuroimage. 2006 May 1;30(4):1285-91. Epub 2006 Jan 10.
- Adult; Blood-Brain Barrier/*physiology; Brain Mapping; *Diffusion Magnetic Resonance Imaging; Dominance, Cerebral/physiology; Female; Frontal Lobe/*physiopathology; Humans; *Image Processing, Computer-Assisted; Male; Psychiatric Status Rating Scales; Reference Values; Schizophrenia/diagnosis/*physiopathology; Temporal Lobe/*physiopathology
- Schizophrenia has been suggested to be the result of both macroscopic and microscopic abnormalities in the brain. Although no definitive clinico-pathological correlations have been found to reconcile the many facets inherent in this disorder, the recent development of the magnetic resonance diffusion tensor imaging (DTI) has allowed us to gather useful information regarding the microcircuitry of the brain. Specifically, the apparent diffusion coefficient (ADC) reflects the degree of diffusion barriers and heterosynaptic communication for the brain neurotransmitter. Nineteen patients with DSM-IV schizophrenia and 21 age- and sex-matched control subjects participated in DTI, and the severity of the patients' symptoms was evaluated according to the Positive and Negative Syndrome Scale (PANSS). The ADC values were determined and compared between patients and control subjects via voxel-based morphometry. The results show an increased ADC in the bilateral fronto-temporal regions of the schizophrenic patients, as compared with those of the control subjects. In addition, the ADC values in the area of the right insular were correlated with the negative syndromes from the PANSS. Our findings of increased water diffusivity in the fronto-temporal regions of schizophrenic patients and the correlation between negative symptom scales and the ADC in the right insular region indicate that damaged brain microcircuitry might contribute to the pathophysiology of schizophrenia. These findings contribute towards integrating micro and macrostructural abnormalities and syndromes of schizophrenia.
- 1053-8119 (Print)
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