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Prevalence of naturally occurring surface antigen variants of hepatitis B virus in Korean patients infected chronically

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dc.contributor.authorSong, Byung-Cheol-
dc.contributor.authorKim, Sun-Hyun-
dc.contributor.authorKim, Hong-
dc.contributor.authorYing, Yuan-Hai-
dc.contributor.authorKim, Hyun-Ju-
dc.contributor.authorKim, Yoon-Jun-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorLee, Hyo-Suk-
dc.contributor.authorCha, Chang-Yong-
dc.contributor.authorKook, Yoon-Hoh-
dc.contributor.authorKim, Bum-Joon-
dc.date.accessioned2010-01-08T05:29:34Z-
dc.date.available2010-01-08T05:29:34Z-
dc.date.issued2005-04-19-
dc.identifier.citationJ Med Virol. 2005 Jun;76(2):194-202.en
dc.identifier.issn0146-6615 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15834881-
dc.identifier.urihttp://hdl.handle.net/10371/28923-
dc.description.abstractAlthough Korea is one of the endemic areas of hepatitis B virus (HBV) infection, the prevalence of naturally occurring variants in the major hydrophilic region (MHR) of the surface (S) gene of HBV has not been determined. In the present study, the prevalence of these variants was examined in terms of the clinical state, and HBeAg serostatus in a large series of Korean patients with chronic HBV infection by direct sequencing analysis of part of the S gene containing the MHR of HBV isolated from 101 chronic HBV patients (51 HBeAg-positive and 50 HBeAg-negative): 37 were asymptomatic carriers, 21 had chronic hepatitis, 20 had liver cirrhosis, and 23 had hepatocellular carcinoma (HCC). Forty-seven MHR variants (46.5%) of the 101 patients were detected, involving a total of 59 amino acid substitutions at 12 positions inside and 14 position outside the 'a' determinant, and 33 'a' determinant variants (32.7%). A total of 17 novel variants and 14 novel mutation patterns were detected. The prevalence of MHR variants in HBeAg-negative patients tended to be higher than in HBeAg-positive patients (54.0% vs.39.2%) and the prevalence of MHR variants in HCC and liver cirrhosis tended to be higher than in asymptomatic carriers (65.2% vs. 40.5% and 50.0% vs. 40.5%, respectively). In conclusion, three important findings were found in the present study. First, an unexpectedly high prevalence of naturally occurring MHR variants was found in Korean chronic patients. Second, several novel variants associated with mutations outside the 'a' determinant were detected. Finally, a higher prevalence of MHR variants was associated with HBeAg-negative serostatus and severe liver disease, particularly HCC.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAmino Acid Substitutionen
dc.subjectCarcinoma, Hepatocellular/virologyen
dc.subjectCarrier State/virologyen
dc.subjectChilden
dc.subjectDNA, Viral/chemistryen
dc.subjectFemaleen
dc.subject*Genetic Variationen
dc.subjectHepatitis B Surface Antigens/*geneticsen
dc.subjectHepatitis B e Antigens/blooden
dc.subjectHepatitis B virus/*genetics/immunology/isolation & purificationen
dc.subjectHepatitis B, Chronic/*virologyen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectLiver Cirrhosis/virologyen
dc.subjectLiver Neoplasms/virologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Mutationen
dc.subjectSequence Analysis, DNAen
dc.subjectViral Envelope Proteins/geneticsen
dc.titlePrevalence of naturally occurring surface antigen variants of hepatitis B virus in Korean patients infected chronicallyen
dc.typeArticleen
dc.contributor.AlternativeAuthor송병철-
dc.contributor.AlternativeAuthor김선현-
dc.contributor.AlternativeAuthor김홍-
dc.contributor.AlternativeAuthor김현주-
dc.contributor.AlternativeAuthor김윤준-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor이효석-
dc.contributor.AlternativeAuthor차창용-
dc.contributor.AlternativeAuthor국윤호-
dc.contributor.AlternativeAuthor김범준-
dc.identifier.doi10.1002/jmv.20354-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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