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Sentinel node identification rate, but not accuracy, is significantly decreased after pre-operative chemotherapy in axillary node-positive breast cancer patients

Cited 65 time in Web of Science Cited 75 time in Scopus
Authors
Lee, See youn; Kim, Eun Young; Kang, Seok Hyung; Kim, Seok Won; Kim, Seok-Ki; Kang, Keon Wook; Kwon, Youngmee; Shin, Kyung Hwan; Kang, Han-Sung; Ro, Jungsil; Lee, Eun Sook
Issue Date
2006-10-26
Publisher
Springer Verlag
Citation
Breast Cancer Res Treat. 2007 May;102(3):283-8. Epub 2006 Oct 25.
Keywords
Antineoplastic Agents/*therapeutic useAxillaBreast Neoplasms/drug therapy/*pathology/surgeryFalse Negative ReactionsFemaleHumans*Lymph Node ExcisionLymphatic Metastasis/*diagnosisMiddle Aged*Neoadjuvant TherapyNeoplasm StagingPredictive Value of TestsSensitivity and Specificity*Sentinel Lymph Node Biopsy
Abstract
BACKGROUND: The aim was to prove the low identification rate of sentinel lymph node biopsy (SNB) and to determine the feasibility of replacing axillary lymph node dissection (AND) in axillary lymph node positive patients after chemotherapy. METHODS: From October 2001 to July 2005, 875 consecutive patients with primary operable breast cancer underwent SNB and AND. Among them, 238 received pre-operative chemotherapy. We compared the identification rate, false negative rate (FNR), negative predictive value (NPV), and accuracy of SNB in clinically node-positive patients with or without chemotherapy. RESULTS: The identification rate was significantly lower in patients received chemotherapy (77.6%) than in those not received it (97.0%) (P<0.001). In those received the therapy, the FNR was 5.6%, the NPV was 86.8%, and the accuracy was 95.9%. In those not received therapy, the FNR was 7.4% and the accuracy was 92.6% (differences not statistically significant). CONCLUSION: The identification rate in confirmed axillary lymph node-positive patients was significantly lower in patients received pre-operative chemotherapy, but accuracy did not differ significantly between the two groups. Thus, for patients who achieve complete axillary clearance by chemotherapy, SNB could replace AND.
ISSN
0167-6806 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17063280

http://hdl.handle.net/10371/28930
DOI
https://doi.org/10.1007/s10549-006-9330-9
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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