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Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Yong Min | - |
dc.contributor.author | Seo, Myoung Suk | - |
dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Kim, Yeni | - |
dc.contributor.author | Yoon, Se Chang | - |
dc.contributor.author | Juhnn, Yong-Sung | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.date.accessioned | 2010-01-08T08:00:44Z | - |
dc.date.available | 2010-01-08T08:00:44Z | - |
dc.date.issued | 2005-05-10 | - |
dc.identifier.citation | Int J Neuropsychopharmacol. 2005 Dec;8(4):607-13. Epub 2005 May 9. | en |
dc.identifier.issn | 1461-1457 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15877933 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29013 | - |
dc.description.abstract | GSK-3beta is regarded as playing an important part in the pathogenesis of schizophrenia and the action of psychotomimetic agents. We observed phosphorylation of molecules associated with the GSK-3beta signalling pathway in the rat brain after MK-801 injection, which induces a schizophrenia-like state in humans. Ser9-GSK-3beta phosphorylation was increased after injection of 1 mg/kg MK-801 in the rat frontal cortex but not in the hippocampus or cerebellum. This increase peaked at 30 min and was maintained until 90 min after injection. The phosphorylation showed a dose-dependent increase up to 1 mg/kg MK-801, followed by a decrease at higher dosage. Furthermore, phosphorylation of Ser473-Akt and Ser133-CREB showed similar temporal, dose-dependent and regionally specific patterns with those of Ser9-GSK-3beta. However, phosphorylation of Dvl and Ser33-beta-catenin was not affected by MK-801. These results suggest that GSK-3beta phosphorylation by MK-801 may be associated with the Akt-GSK-3beta pathway rather than with the Wnt-Dvl-GSK3beta pathway. | en |
dc.language.iso | en | en |
dc.publisher | Cambridge University Press | en |
dc.subject | Actins/metabolism | en |
dc.subject | Animals | en |
dc.subject | Blotting, Western | en |
dc.subject | Catenins/metabolism | en |
dc.subject | Cyclic AMP Response Element-Binding Protein/*metabolism | en |
dc.subject | Dizocilpine Maleate/administration & dosage/*pharmacology | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Excitatory Amino Acid Antagonists/administration & dosage/*pharmacology | en |
dc.subject | Glycogen Synthase Kinase 3/*metabolism | en |
dc.subject | Injections, Intraperitoneal | en |
dc.subject | Male | en |
dc.subject | Phosphorylation | en |
dc.subject | Prefrontal Cortex/drug effects/*metabolism | en |
dc.subject | Proto-Oncogene Proteins c-akt/*metabolism | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Serine/*metabolism | en |
dc.title | Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.contributor.AlternativeAuthor | 서명숙 | - |
dc.contributor.AlternativeAuthor | 김세현 | - |
dc.contributor.AlternativeAuthor | 김예니 | - |
dc.contributor.AlternativeAuthor | 윤세창 | - |
dc.contributor.AlternativeAuthor | 전용성 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.identifier.doi | 10.1017/S1461145705005353 | - |
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