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One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia

Cited 42 time in Web of Science Cited 40 time in Scopus
Authors
Lee, Kyoung-Mu; Lan, Qing; Kricker, Anne; Purdue, Mark P; Grulich, Andrew E; Vajdic, Claire M; Turner, Jennifer; Whitby, Denise; Kang, Daehee; Chanock, Stephen; Rothman, Nathaniel; Armstrong, Bruce K
Issue Date
2007-09-25
Publisher
Springer Verlag
Citation
Hum Genet. 2007 Dec;122(5):525-33. Epub 2007 Sep 21.
Keywords
AdultAgedAllelesAustraliaCarbon/*metabolismCase-Control StudiesFemaleGenotypeHumansLymphoma, B-Cell/etiology/genetics/metabolismLymphoma, Non-Hodgkin/etiology/*genetics/*metabolismLymphoma, T-Cell/etiology/genetics/metabolismMaleMiddle AgedModels, Biological*Polymorphism, Single NucleotideRisk Factors
Abstract
Dysregulation of the one-carbon metabolic pathway, which controls nucleotide synthesis and DNA methylation, may promote lymphomagenesis. We evaluated the association between polymorphisms in one-carbon metabolism genes and risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study in Australia. Cases (n = 561) and controls (n = 506) were genotyped for 14 selected single-nucleotide polymorphisms in 10 genes (CBS, FPGS, FTHFD, MTHFR, MTHFS, MTR, SHMT1, SLC19A1, TCN1, and TYMS). We also conducted a meta-analysis of all studies of Caucasian populations investigating the association between MTHFR Ex5+79C > T (a.k.a., 677C>T) and NHL risk. A global test of 13 genotypes was statistically significant for diffuse large B-cell lymphoma (DLBCL; P = 0.008), but not for follicular lymphoma (FL; P = 0.27) or all NHL (P = 0.17). The T allele at MTHFR Ex5+79 was marginally significantly associated with all NHL (OR = 1.25, 95% CI = 0.98-1.59) and DLBCL (1.36, 0.96-1.93). The T allele at TYMS Ex8+157 was associated with a reduced risk of FL (0.64, 0.46-0.91). An elevated risk of NHL was also observed among carriers of the G allele at FTHFD Ex21+31 (all NHL, 1.31, 1.02-1.69; DLBCL, 1.50, 1.05-2.14). A meta-analysis of 11 studies conducted in Caucasian populations of European origin (4,121 cases and 5,358 controls) supported an association between the MTHFR Ex5+79 T allele and increased NHL risk (additive model, P = 0.01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL.
ISSN
1432-1203 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17891500

https://hdl.handle.net/10371/29046
DOI
https://doi.org/10.1007/s00439-007-0431-2
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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