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Developmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal cord
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sang Wook | - |
dc.contributor.author | Lim, Ha Seong | - |
dc.contributor.author | Roh, Eun Jung | - |
dc.contributor.author | Kim, Dong Woon | - |
dc.contributor.author | Jeon, Gye Sun | - |
dc.contributor.author | Cho, Sa Sun | - |
dc.date.accessioned | 2010-01-08T08:21:19Z | - |
dc.date.available | 2010-01-08T08:21:19Z | - |
dc.date.issued | 2006-12-08 | - |
dc.identifier.citation | Neurochem Res. 2007 Jan;32(1):11-8. Epub 2006 Dec 6. | en |
dc.identifier.issn | 0364-3190 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17151919 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29054 | - |
dc.description.abstract | Oligodendrocytes develop from precursor cells in the neuroepithelium of the ventral ventricular zone. Oligodendrocytes in the different stages of development are characterized by expression of a number of different marker molecules such as myelin genes, growth factors, and specific antigens. We have previously identified that transferrin binding protein (TfBP), a member of heat shock protein 90 families, is a novel avian ER-associated membrane protein that is specifically localized in oligodendrocytes in adult chicken CNS. In this study we describe the developmental expression of TfBP in the embryonic chick spinal cord. A few, distinct, TfBP+ cells appeared at the lateral margin of the subventricular neuroepithelium of the spinal cord at E7. Thereafter, some TfBP+ cells, exhibited a migrative form of unipolar or bipolar shape occurred around E8 in the mantle layer, midway between the neuroepithelium and the marginal layer of the primitive spinal cord. Thereafter, the TfBP+ cells rapidly increased in number as well as their staining intensity, and overall distribution of TfBP+ cells at E15 was comparable to that of a mature spinal cord. Our observations suggest that TfBP is expressed in the subpopulation of oligodendrocyte lineage in the development and a putative role of TfBP in relation to transferrin and iron trafficking is considered. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Animals | en |
dc.subject | Blotting, Western | en |
dc.subject | Cell Lineage | en |
dc.subject | Chick Embryo | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Microscopy, Fluorescence | en |
dc.subject | Oligodendroglia/cytology/immunology/*metabolism | en |
dc.subject | Spinal Cord/embryology | en |
dc.subject | Transferrin-Binding Proteins/*biosynthesis | en |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.title | Developmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal cord | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박상욱 | - |
dc.contributor.AlternativeAuthor | 임하승 | - |
dc.contributor.AlternativeAuthor | 노은정 | - |
dc.contributor.AlternativeAuthor | 김동운 | - |
dc.contributor.AlternativeAuthor | 전계선 | - |
dc.contributor.AlternativeAuthor | 조사선 | - |
dc.identifier.doi | 10.1007/s11064-006-9216-6 | - |
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