S-Space College of Medicine/School of Medicine (의과대학/대학원) Radiation Oncology (방사선종양학전공) Journal Papers (저널논문_방사선종양학전공)
Clinical results of stereotactic body frame based fractionated radiation therapy for primary or metastatic thoracic tumors
- Yoon, Sang Min; Choi, Eun Kyung; Lee, Sang-Wook; Yi, Byong Yong; Ahn, Seung Do; Shin, Seong Soo; Park, Heon Joo; Kim, Su Ssan; Park, Jin-Hong; Song, Si Yeol; Park, Charn Il; Kim, Jong Hoon
- Issue Date
- Taylor & Francis
- Acta Oncol. 2006;45(8):1108-14.
- Adolescent; Adult; Aged; Aged, 80 and over; Child; Dose Fractionation; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiosurgery/*instrumentation; Survival Rate; Thoracic Neoplasms/*surgery; Treatment Outcome
- The aim of this study was to evaluate the treatment outcomes of stereotactic body radiation therapy for treating primary or metastatic thoracic tumors using a stereotactic body frame. Between January 1998 and February 2004, 101 lesions from 91 patients with thoracic tumors were prospectively reviewed. A dose of 10-12 Gy per fraction was given three to four times over consecutive days to a total dose of 30-48 Gy (median 40 Gy). The overall response rate was 82%, with 20 (22%) complete responses and 55 (60%) partial responses. The one- and two-year local progression free survival rates were 90% and 81%, respectively. The patients who received 48 Gy showed a better local tumor control than those who received less than 48 Gy (Fisher exact test; p = 0.004). No pulmonary complications greater than a RTOG toxicity criteria grade 2 were observed. The experience of stereotactic body frame based radiation therapy appears to be a safe and promising treatment modality for the local management of primary or metastatic lung tumors. The optimal total dose, fractionation schedule and treatment volume need to be determined after a further follow-up of these results.
- 0284-186X (Print)
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