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Clinical results of stereotactic body frame based fractionated radiation therapy for primary or metastatic thoracic tumors
Cited 33 time in
Web of Science
Cited 36 time in Scopus
- Authors
- Issue Date
- 2006-11-23
- Publisher
- Taylor & Francis
- Citation
- Acta Oncol. 2006;45(8):1108-14.
- Keywords
- Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Dose Fractionation ; Female ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography ; Radiosurgery/*instrumentation ; Survival Rate ; Thoracic Neoplasms/*surgery ; Treatment Outcome
- Abstract
- The aim of this study was to evaluate the treatment outcomes of stereotactic body radiation therapy for treating primary or metastatic thoracic tumors using a stereotactic body frame. Between January 1998 and February 2004, 101 lesions from 91 patients with thoracic tumors were prospectively reviewed. A dose of 10-12 Gy per fraction was given three to four times over consecutive days to a total dose of 30-48 Gy (median 40 Gy). The overall response rate was 82%, with 20 (22%) complete responses and 55 (60%) partial responses. The one- and two-year local progression free survival rates were 90% and 81%, respectively. The patients who received 48 Gy showed a better local tumor control than those who received less than 48 Gy (Fisher exact test; p = 0.004). No pulmonary complications greater than a RTOG toxicity criteria grade 2 were observed. The experience of stereotactic body frame based radiation therapy appears to be a safe and promising treatment modality for the local management of primary or metastatic lung tumors. The optimal total dose, fractionation schedule and treatment volume need to be determined after a further follow-up of these results.
- ISSN
- 0284-186X (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17118847
https://hdl.handle.net/10371/29072
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