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Genetic polymorphisms in the transforming growth factor beta-induced gene associated with BMI

Cited 6 time in Web of Science Cited 6 time in Scopus
Authors
Park, Kyong Soo; Shin, Hyoung Doo; Park, Byung Lae; Cheong, Hyun Sub; Choa, Young Min; Lee, Hong Kyu; Lee, Jong-Young; Lee, Jong-Keuk; Kim, Hung Tae; Han, Bok Ghee; Kim, Jun Woo; Koh, InSong; Kim, Young Jin; Kimm, Kuchan; Oh, Bermseok
Issue Date
2005-02-16
Publisher
Wiley-Blackwell
Citation
Hum Mutat. 2005 Mar;25(3):322.
Keywords
3' Untranslated Regions/geneticsAgedAllelesAmino Acid SubstitutionBlood Glucose/analysis*Body Mass IndexCholesterol/bloodCholesterol, HDL/bloodDiabetes Mellitus, Type 2/blood/*geneticsExons/geneticsExtracellular Matrix Proteins/*genetics/physiologyFemaleGenetic Predisposition to DiseaseGenotypeHemoglobin A, Glycosylated/analysisHumansInsulin/bloodInsulin Resistance/geneticsIntrons/geneticsKoreaMaleMiddle AgedMutation, Missense*Polymorphism, GeneticPolymorphism, Single NucleotidePromoter Regions, Genetic/geneticsRiskTransforming Growth Factor beta/*genetics/physiologyTriglycerides/bloodWaist-Hip Ratio
Abstract
In an effort to identify genetic polymorphisms in potential candidate genes for type 2 diabetes mellitus (T2DM), we have sequenced the transforming growth factor beta-induced gene (TGFBI), and examined the association with T2DM and diabetic phenotypes in a Korean T2DM study (775 T2DM patients and 316 normal controls). Twenty-eight polymorphisms were identified in TGFBI. Although no significant associations were detected with the risk of T2DM, one SNP in intron 16 (c.2011+137C>T) and one SNP in the 3' untranslated region (UTR) (c.2589T>G), showed significant association with the levels of insulin and body mass index (BMI) among nondiabetic controls. The lower insulin and BMI were observed in individuals who carry one or two copies of minor alleles than others. For example, the highest BMI (24.21 kg/m(2)) in individuals with homozygote major alleles (T) of c.2589T>G (n=99), the intermediate BMI (23.68 kg/m(2)) in individuals with heterozygote alleles (n=156), and the lowest BMI (22.69 kg/m(2)) in individuals with homozygote minor alleles (G) (n=57, P=0.005) were observed. The present study provides, for the first time, information about genetic polymorphisms in TGFBI and positive associations of those polymorphisms with levels of insulin and BMI in the Korean population.
ISSN
1098-1004 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15712349

https://hdl.handle.net/10371/29086
DOI
https://doi.org/10.1002/humu.9315
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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