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Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors
Yoon, Su-Jung; Pae, Chi-Un; Lee, Heejin; Choi, Bomoon; Kim, Tae-Suk; Lyoo, In Kyoon; Kwon, Do-Hoon; Kim, Dai-Jin
Issue Date
2005-10-07
Publisher
Elsevier
Citation
Neurosci Res. 2005 Dec;53(4):391-5. Epub 2005 Oct 3.
Keywords
AdultCentral Nervous System Stimulants/*pharmacologyFemaleGenetic Predisposition to DiseaseGenotypeGhrelinHumansKorea/epidemiologyMaleMethamphetamine/*pharmacologyMiddle AgedMotilin/*genetics*Polymorphism, GeneticReverse Transcriptase Polymerase Chain ReactionSubstance-Related Disorders/*genetics
Abstract
Ghrelin is a recently isolated brain-gut peptide that has growth hormone-releasing and appetite-inducing activities. Several recent studies have suggested that ghrelin plays a major role in the pathophysiology of drug-seeking behavior and anxiety. Therefore, we assessed the effect of the ghrelin precursor polymorphism on methamphetamine dependence in the Korean population. One hundred and eighteen patients with methamphetamine dependence, according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria, and the 144 healthy controls were enrolled in this study. Genotyping for the ghrelin precursor polymorphism was performed by the polymerase chain reaction-restriction fragment length polymorphism-based technique. The genotypic and allelic distributions of the ghrelin precursor polymorphism in the patients with methamphetamine dependence were not significantly different from those of the control subjects. However, the Met72 carriers were associated with the emotional problems of methamphetamine dependence. The patients with the Met72 allele were more depressed and anxious than the homozygous patients with the wild Leu72 allele. The present study suggests that the ghrelin precursor polymorphism may not confer a susceptibility to the development of methamphetamine dependence in the Korean population. However, the Leu72Met polymorphism could have a potential role in the emotional problems that are associated with this disease.
ISSN
0168-0102 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16207498

https://hdl.handle.net/10371/29098
DOI
https://doi.org/10.1016/j.neures.2005.08.013
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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