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Transforming growth factor-[beta]1 -509T reduces risk of colorectal cancer, but not adenoma in Koreans

Cited 16 time in Web of Science Cited 17 time in Scopus
Authors
Chung, Su J; Kim, Joo S; Jung, Hyun C; Song, In S
Issue Date
2007-01-12
Publisher
Wiley-Blackwell
Citation
Cancer Sci. 2007 Mar;98(3):401-4.
Keywords
Adenoma/*genetics/pathologyCase-Control StudiesColorectal Neoplasms/*genetics/pathologyFemaleHumansKorea/epidemiologyLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPolymorphism, Genetic*Polymorphism, Single NucleotideProspective StudiesRisk FactorsTransforming Growth Factor beta1/*genetics
Abstract
The proliferation of colorectal epithelial cells is regulated by various stimuli including cytokines and growth factors, thus the variants of those genes can modify the colorectal cancer risk. TGF-[beta]1 can act as both a tumor suppressor and a stimulator of tumor progression. TGF-[beta]1 C-509T polymorphism in the promoter sequence has been associated with increased levels of plasma TGF-[beta]1 in individuals with T allele. To evaluate the potential influences of this polymorphism on colorectal adenoma and cancer risk, a case-control study was conducted in Korea. A total of 646 subjects were prospectively enrolled in Seoul National University Hospital. Risk of colorectal neoplasms was evaluated separately for 244 patients with colorectal adenoma, 152 patients with colorectal cancer relative to 250 healthy controls. Genotypes were determined by the PCR-RFLP method. ORs and 95% CIs were calculated by a multivariate logistic regression analysis. The TGF-[beta]1 -509T allele containing genotypes posed a reduced risk of colorectal cancer (adjusted OR = 0.59, 95% CI = 0.28-0.92). But there was no association between this polymorphism and colorectal adenoma. Our results suggest that the TGF-[beta]1 -509T allele may have a protective role in the development of colorectal cancer, possibly consistent with its role as an inhibitor of epithelial malignant transformation.
ISSN
1347-9032 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17214746

https://hdl.handle.net/10371/29120
DOI
https://doi.org/10.1111/j.1349-7006.2007.00401.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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