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Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism

Cited 18 time in Web of Science Cited 20 time in Scopus
Authors
Woo, So-Youn; Lee, Mi-Young; Jung, Yun-Jae; Yoo, Eun-Sun; Seoh, Ju-Young; Shin, Hee-Young; Ahn, Hyo-Seop; Ryu, Kyung-Ha
Issue Date
2006-03-07
Publisher
Taylor & Francis
Citation
Pediatr Hematol Oncol. 2006 Apr-May;23(3):231-43.
Keywords
Antineoplastic Agents/*pharmacologyApoptosis/*drug effectsArsenicals/*pharmacologyCDC2 Protein Kinase/biosynthesis/geneticsCaspase 3Caspases/metabolismCell Cycle/*drug effectsCell Line, Tumor/drug effectsCyclin-Dependent Kinase Inhibitor p27/biosynthesis/geneticsCyclin-Dependent Kinases/biosynthesis/geneticsCyclins/biosynthesis/geneticsDose-Response Relationship, DrugEnzyme Activation/drug effectsG2 Phase/drug effectsGene Expression Regulation/*drug effectsHL-60 Cells/drug effectsHumansMetaphase/drug effectsNF-kappa B/*metabolismNeoplasm Proteins/biosynthesis/geneticsNeuroblastoma/*pathologyOxidative StressOxides/*pharmacologyPoly(ADP-ribose) Polymerases/metabolismProto-Oncogene Proteins c-bcl-2/metabolismS Phase/drug effects
Abstract
Neuroblastoma, characterized by heterogeneous cell population, is a common solid tumor in childhood and some malignant neuroblastomas are refractory to conventional chemotherapy. Recently, treatment with arsenic trioxide (As2O3) was found effective in the treatment of acute promyelocytic leukemia as well as neuroblastoma cells by inducing apoptosis. To define the mechanism contributing to cell death in those heterogenous cell populations, the authors used two different types of neuroblastoma cells, SH-SY5Y and SK-N-AS, to compare the pathways that mediate death response to arsenic trioxide. With arsenic trioxide exposure, both cell lines were arrested at the S-G2/M phase with the increase of cyclin B expression and CDK1 activity. Although caspase 3 was activated in both cell lines, the NF-kappaB activity and the expression of cyclin D1, cyclin E, and p27 were different. Therefore, arsenic trioxide could be an effective cytotoxic drug for the treatment of heterogeneous cellular population of neuroblastoma.
ISSN
1521-0669 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16517539

http://hdl.handle.net/10371/29256
DOI
https://doi.org/10.1080/08880010500506818
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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