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Postnatal developmental changes in Ca2+ homeostasis in supraoptic magnocellular neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang Hun | - |
dc.contributor.author | Park, Kyeong Han | - |
dc.contributor.author | Ho, Won-Kyung | - |
dc.contributor.author | Lee, Suk-Ho | - |
dc.date.accessioned | 2010-01-11T01:21:07Z | - |
dc.date.available | 2010-01-11T01:21:07Z | - |
dc.date.issued | 2006-10-03 | - |
dc.identifier.citation | Cell Calcium. 2007 May;41(5):441-50. Epub 2006 Sep 27. | en |
dc.identifier.issn | 0143-4160 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17010427 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29264 | - |
dc.description.abstract | Supraoptic magnocellular neurons (SMNs) undergo dramatic changes in morphological and electrical properties during postnatal development. We investigated the developmental change in Ca2+ homeostasis in SMNs. The decay rate of Ca2+ transients markedly increased during the third postnatal week (PW3) to an adult level. This increase in the Ca2+ decay rate was paralleled by hypertrophy of the SMN somata. Activity of Na+/Ca2+ exchanger (Na/CaX) and sarcoendoplasmic reticulum Ca2+-ATPase (SERCA) was quantified as a decrement in the Ca2+ decay rate caused by extracellular [Na+] reduction and that by thapsigargin, respectively. SERCA activity was negligible during PW2, and markedly increased during PW3. SERCA activity and soma size remained stable thereafter. Na/CaX activity was a major Ca2+-clearance mechanism (CCM) during PW2, increased further during PW3, but was negligible in mature SMNs (PW10). In parallel with the decrease in Na/CaX activity, endogenous Ca2+ buffering capacity declined, resulting that the apparent Ca2+ decay rate remained relatively constant between PW4 and PW10. Replacement of intracellular K+ with Li+ had no effect on Na/CaX activity, suggesting that NCX rather than NCKX comprises Na/CaX. These findings indicate a developmental shift in the balance of CCMs from Ca2+ extrusion via NCX toward Ca2+ sequestration into endoplasmic reticulum via SERCA. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Animals, Newborn | en |
dc.subject | Caffeine/pharmacology | en |
dc.subject | Calcium/*metabolism | en |
dc.subject | Calcium Signaling/drug effects | en |
dc.subject | Male | en |
dc.subject | Neurons/cytology/drug effects/enzymology/*metabolism | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism | en |
dc.subject | Sodium/pharmacology | en |
dc.subject | Sodium-Calcium Exchanger/metabolism | en |
dc.subject | Supraoptic Nucleus/*cytology/*growth & development | en |
dc.subject | Thapsigargin/pharmacology | en |
dc.subject | Homeostasis/drug effects | - |
dc.title | Postnatal developmental changes in Ca2+ homeostasis in supraoptic magnocellular neurons | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이상헌 | - |
dc.contributor.AlternativeAuthor | 박경한 | - |
dc.contributor.AlternativeAuthor | 호원경 | - |
dc.contributor.AlternativeAuthor | 이석호 | - |
dc.identifier.doi | 10.1016/j.ceca.2006.08.003 | - |
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