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Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels
DC Field | Value | Language |
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dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Son, Youn Kyoung | - |
dc.contributor.author | Kim, Nari | - |
dc.contributor.author | Ko, Jae-Hong | - |
dc.contributor.author | Kang, Sung Hyun | - |
dc.contributor.author | Warda, Mohamad | - |
dc.contributor.author | Earm, Yung E. | - |
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.contributor.author | Han, Jin | - |
dc.date.accessioned | 2010-01-11T07:04:24Z | - |
dc.date.available | 2010-01-11T07:04:24Z | - |
dc.date.issued | 2007-05-09 | - |
dc.identifier.citation | Pflugers Arch. 2007 Sep;454(6):1023-30. Epub 2007 May 8. | en |
dc.identifier.issn | 0031-6768 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17486361 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29351 | - |
dc.description.abstract | We examined the effects of acute hypoxia on vascular tone and coronary blood flow (CBF) in rabbit coronary arteries. In the pressurized arterial preparation of small arteries (<100 mum) and the Langendorff-perfused rabbit hearts, hypoxia induced coronary vasodilation and increased CBF in the presence of glibenclamide (K(ATP) channel blocker), Rp-8-Br-PET-cGMPs [cyclic guanosine monophosphate (cGMP)-dependent protein kinase inhibitor, Rp-cGMPs], and methionyl transfer RNA synthetase (MRS) 1334 (adenosine A(3) receptor inhibitor); these increases were inhibited by the inward rectifier K(+) (Kir) channel inhibitor, Ba(2+). These effects were blocked by the adenylyl cyclase inhibitor SQ 22536 and by the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) inhibitors Rp-8-CPT-cAMPs (Rp-cAMPs) and KT 5720. However, cGMP-dependent protein kinase was not involved in the hypoxia-induced increases of the vascular diameter and CBF. In summary, our results suggest that acute hypoxia can induce the opening of Kir channels in coronary artery that has small diameter (<100 mum) by activating the cAMP and PKA signalling pathway, which could contribute to vasodilation and, therefore, increased CBF. | en |
dc.language.iso | en | en |
dc.publisher | Springer-Verlag | en |
dc.subject | Acute Disease | en |
dc.subject | Adenine/analogs & derivatives/pharmacology | en |
dc.subject | Animals | en |
dc.subject | Anoxia/*physiopathology | en |
dc.subject | Blood Pressure/physiology | en |
dc.subject | Carbazoles/pharmacology | en |
dc.subject | Coronary Circulation/*physiology | en |
dc.subject | Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors | en |
dc.subject | Cyclic GMP/analogs & derivatives/pharmacology | en |
dc.subject | Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors | en |
dc.subject | Enzyme Inhibitors/pharmacology | en |
dc.subject | Female | en |
dc.subject | Glyburide/pharmacology | en |
dc.subject | Indoles/pharmacology | en |
dc.subject | Male | en |
dc.subject | Potassium Channel Blockers/pharmacology | en |
dc.subject | Potassium Channels, Inwardly Rectifying/drug effects/*physiology | en |
dc.subject | Pyrroles/pharmacology | en |
dc.subject | Rabbits | en |
dc.subject | Signal Transduction/physiology | en |
dc.subject | Vasodilation/*physiology | en |
dc.title | Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박원선 | - |
dc.contributor.AlternativeAuthor | 손연경 | - |
dc.contributor.AlternativeAuthor | 김나리 | - |
dc.contributor.AlternativeAuthor | 고재홍 | - |
dc.contributor.AlternativeAuthor | 강성현 | - |
dc.contributor.AlternativeAuthor | 엄융의 | - |
dc.contributor.AlternativeAuthor | 정인덕 | - |
dc.contributor.AlternativeAuthor | 박영민 | - |
dc.contributor.AlternativeAuthor | 한진 | - |
dc.identifier.doi | 10.1007/s00424-007-0269-4 | - |
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